Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge

摘要

Four new pregnane steroids, 311,413,16/4-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16 beta-acetoxy3 beta,4 beta-dihydroxypregna-5,17-diene-10,2-carbolactone (2), 12 beta-acetoxy-3 beta,4 beta,16 beta-trihydroxypregna-5,17-diene-10,2-carbolactone 0), and 12 beta,16 beta-diacetoxy-3 beta,4 beta-dihydroxypregna-5,17-diene-10,2-carbolactone (4) were isolated from an extract of an Epipolasis sp. marine sponge. The structures of the new compounds were determined by extensive NMR spectroscopic analysis and comparison with data from previously reported compounds.