Fe3O4@TiO2@ILs-ZIF-8 Nanocomposite: A Robust Catalyst for the Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidines

摘要

Zeolitic imidazolate frameworks (prototype system ZIF-8) supported on the Fe3O4@TiO2@ILs magnetic nanostructure (Fe3O4@TiO2@ILs-ZIF-8) was first synthesized and it showed high catalytic activity for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives. The multi-component reactions of various aldehydes, 2-aminobenzimidazole and ethyl acetoacetate were efficiently catalyzed using a novel magnetic nanocatalyst at room temperature. The nanocatalyst was easily separated from the reaction media by an external magnet and its catalytic behavior was remained significantly after six runs. The catalyst was fully characterized by FT-IR, SEM, TGA, XRD, EDX, TEM, and VSM analyses. The present methodology offers various advantages such as, excellent yields, simple procedures, short reaction times, simple workup and mild reaction conditions. (C) 2021 Elsevier B.V. All rights reserved.