The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study

Lewis Daniel; Donofrio Carmine A.; OLeary Claire; Li Ka-Loh; Zhu Xiaoping; Williams Ricky; Djoukhadar Ibrahim; Agushi Erjon; Hannan Cathal J.; Stapleton Emma; Lloyd Simon K.; Freeman Simon R.; Wadeson Andrea; Rutherford Scott A.; Hammerbeck-Ward Charlotte; Evans D. Gareth; Jackson Alan; Pathmanaban Omar N.; Roncaroli Federico; King Andrew T.; Coope David J.

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The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study

机译：散发性和神经纤维瘤症的微环境相关II相关的前庭施瓦南马：相同的肿瘤或不同？比较影像学和神经病理学研究

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OBJECTIVE Inflammation and angiogenesis may play a role in the growth of sporadic and neurofibromatosis type 2 (NF2)-related vestibular schwannoma (VS). The similarities in microvascular and inflammatory microenvironment have not been investigated. The authors sought to compare the tumor microenvironment (TME) in sporadic and NF2-related VSs using a combined imaging and tissue analysis approach.

机译：目的炎症和血管生成可能在散发性和神经纤维瘤病2型（NF2）相关前庭神经鞘瘤（VS）的生长中起作用。微血管和炎症微环境的相似性尚未被研究。作者试图使用联合成像和组织分析方法，比较散发性VSs和NF2相关VSs中的肿瘤微环境（TME）。

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来源
《Journal of neurosurgery.》 |2021年第5期|共11页
作者
Lewis Daniel; Donofrio Carmine A.; OLeary Claire; Li Ka-Loh; Zhu Xiaoping; Williams Ricky; Djoukhadar Ibrahim; Agushi Erjon; Hannan Cathal J.; Stapleton Emma; Lloyd Simon K.; Freeman Simon R.; Wadeson Andrea; Rutherford Scott A.; Hammerbeck-Ward Charlotte; Evans D. Gareth; Jackson Alan; Pathmanaban Omar N.; Roncaroli Federico; King Andrew T.; Coope David J.;
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作者单位

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Univ Manchester Wolfson Mol Imaging Ctr WMIC Div Informat Imaging &

Data Sci Manchester Lancs;

Univ Manchester Wolfson Mol Imaging Ctr WMIC Div Informat Imaging &

Data Sci Manchester Lancs;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Univ Manchester Wolfson Mol Imaging Ctr WMIC Div Informat Imaging &

Data Sci Manchester Lancs;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Dept Otolaryngol Salford Greater;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Dept Otolaryngol Salford Greater;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Dept Otolaryngol Salford Greater;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Univ Manchester Fac Biol Med &

Hlth Sch Biol Sci Div Evolut &

Genom Sci Manchester Lancs;

Univ Manchester Wolfson Mol Imaging Ctr WMIC Div Informat Imaging &

Data Sci Manchester Lancs;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

Manchester Acad Hlth Sci Ctr Salford Royal NHS Fdn Trust Manchester Ctr Clin Neurosci Dept;

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原文格式 PDF
正文语种 eng
中图分类头部及神经外科学;
关键词
vestibular schwannoma; neurofibromatosis type 2; NF2; inflammation; DCE-MRI; vascular endothelial growth factor; VEGF; oncology;

机译：前庭施瓦马瘤;神经纤维瘤病2型;NF2;炎症;DCE-MRI;血管内皮生长因子;VEGF;肿瘤学;

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专利

1. Gastrointestinal Stromal Tumors with KIT Mutation Coexisting with Wild-type Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1 [J] . Yang Li, Zhi-Dong Gao, Xiao-Dong Yang, 中华医学杂志（英文版） . 2018,第018期
2. Comparative Study of Images with Pathology:Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Image(MRI)of Splenic VX2 Tumor in Rats [J] . YANG Hong-yan, XU Yi-kai, WU Yuan-kui, 中国癌症研究（英文版） . 2008,第001期
3. Gamma Knife radiosurgery for treatment of growing vestibular schwannomas in patients with neurofibromatosis Type 2: a matched cohort study with sporadic vestibular schwannomas [J] . Kruyt Ivo J., Verheul Jeroen B., Hanssens Patrick E. J., Journal of neurosurgery. . 2018,第1期

机译：伽马刀放射外科治疗神经纤维瘤病患者生长前庭施沃马斯2型：与零星前庭施瓦莫马瘤的竞争队列研究
4. Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype. [J] . Aghi M, Kluwe L, Webster MT, Journal of neurosurgery. . 2006,第2期

机译：单侧前庭神经鞘瘤与其他2型神经纤维瘤病相关的肿瘤：独特表型的临床和分子研究。
5. Contextualizing the Modern Epidemiology of Neurofibromatosis Type 2 in an Era of Heightened Detection of Sporadic Vestibular Schwannoma [J] . Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology . 2020,第4期

机译：在零星前庭施瓦南马脉上升检测时代，神经纤维瘤病2型的现代流行病学
6. Definition of Tumor Size of Vestibular Schwannomas [C] . Shigeaki Kobayashi, Yuichiro Tanaka, Kazuhiro Hongo Keio International Symposium for Life Sciences and Medicine . 2003

机译：前庭施瓦莫纳肿瘤大小的定义
7. Insights from murine models of neurofibromatosis type I: The etiology and appropriate therapeutic windows for peripheral nerve sheath tumors [D] . Chang, Lou 2011

机译：I型神经纤维瘤病鼠模型的见解：周围神经鞘瘤的病因和适当的治疗窗口
8. Long-Term Outcomes of Stereotactic Radiosurgery for Vestibular Schwannoma Associated with Neurofibromatosis Type 2 in Comparison to Sporadic Schwannoma [O] . Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, 2019

机译：与散发性神经鞘瘤相比立体定向放射外科治疗前庭神经鞘瘤与2型神经纤维瘤病相关的长期结果
9. Differential diagnosis of type 2 neurofibromatosis: molecular discrimination of NF2 and sporadic vestibular schwannomas. [O] . Wu, C L, Thakker, N, Neary, W, 1998

机译：2型神经纤维瘤病的鉴别诊断：NF2和散发性前庭神经鞘瘤的分子鉴别。
10. Preclinical Validation of Anti-Nuclear Factor Kappa B Therapy Against Vestibular Schwannoma and Neurofibromatosis Type II. [R] . Stankovic, K. M. 2016

机译：临床前验证抗核因子Kappa治疗前庭神经鞘瘤和II型神经纤维瘤病。

The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study

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