Determination of Pseudoephedrine Hydrochloride in Some Pharmaceutical Drugs by Potentiometric Membrane Sensor Based on Pseudoephedrine-Phosphotungstate Ion Pair

摘要

An ion-selective electrode (ISE) was developed for the rapid determination of pseudoephedrine hydrochloride (PSEHCl) in pharmaceutical preparations. The electrode incorporates a PVC membrane with a pseudoephedrine-phosphotungstate ion pair complex. The influences of membrane composition, temperature, pH of the test solution, and the interfering ions on the electrode performance were investigated. The sensor exhibits a Nernstian response for pseudoephedrine hydrochloride ions over a relatively wide concentration range (1.010-1 to 1.010-5 mol L-1) with a slope of 56.20.5mV per decade at 25C. It can be used in the pH range 4.0-10.5. The isothermal temperature coefficient of this electrode amounted to 0.0009V/C. The membrane sensor was successfully applied to determination of PSEHCl in its tablets and syrup.