Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats

Marcos Antonio  Ferreira Jr.; Hatylas  Azevedo; Alessandra  Mascarello; Natanael Dante  Segretti; Elisa  Russo; Valter  Russo; Cristiano Ruch Werneck  Guimar?es

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Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats

机译：ACH-000143的发现：一种新型有效和外周优选的褪黑激素受体激动剂，可降低饮食诱导的肥胖大鼠肝甘油三酯和脂肪变性

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《Journal of Medicinal Chemistry》 |2021年第4期|共26页
作者
Marcos Antonio Ferreira Jr.; Hatylas Azevedo; Alessandra Mascarello; Natanael Dante Segretti; Elisa Russo; Valter Russo; Cristiano Ruch Werneck Guimar?es;
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Aché Laboratórios Farmacêuticos;

Aché Laboratórios Farmacêuticos;

Aché Laboratórios Farmacêuticos;

Aché Laboratórios Farmacêuticos;

Zirkon Ind. Com de Insumos Químicos;

Zirkon Ind. Com de Insumos Químicos;

Aché Laboratórios Farmacêuticos;

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正文语种 eng
中图分类药学;
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3. The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) [J] . Ziwen Wang, Shanshan Li, Ruifeng Wang, Molecular medicine. . 2020,第1期

机译：β3肾上腺素能受体激动剂BR13744对高脂饮食脂肪肝疾病大鼠肝硬化和炎症肝硬化和炎症的保护作用（NAFLD）
4. The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. [J] . Thornton Jones ZD, Kennett GA, Benwell KR, Pharmacology, Biochemistry and Behavior . 2006,第2期

机译：由于饮食摄入减少，大麻素CB1受体反向激动剂利莫那班改变了饮食诱导的肥胖大鼠的体重和脂联素功能。
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6. Selective Agonists for the Human Vasopressin V_(1b) Receptor are Potent Antidiuretic Agonists in the Rat [C] . Stoytcho B. Stoev, LingLing Cheng, Maurice Manning American Peptide Symposium . 2006

机译：用于人血管加压素V_（1B）受体的选择性激动剂是大鼠有效的抗硫酸激动剂
7. Liver Transcriptomic Analysis After Short- and Long-Term Feeding of Soy Protein Isolate and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats [D] . ?Kozaczek, Melisa 2020

机译：肝转录组分析大豆分离蛋白的短期和长期喂养后及其对减轻肝脏脂肪变性的肥胖 Zucker大鼠能力
8. The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) [O] . Ziwen Wang, Shanshan Li, Ruifeng Wang, 2020

机译：β3肾上腺素能受体激动剂BRL37344对高脂饮食诱发的非酒精性脂肪性肝病（NAFLD）大鼠模型的肝脏脂肪变性和炎症的保护作用
9. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats [O] . Marcos Antonio Ferreira, Hatylas Azevedo, Alessandra Mascarello, 2021

机译：ACH-000143的发现：一种新型有效和外周优选的褪黑激素受体激动剂，可降低饮食诱导的肥胖大鼠肝甘油三酯和脂肪变性

Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats

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