New polyester biodegradable scaffolds for chondrocyte culturing: Preparation, properties, and biological activity

摘要

An innovative modification of the wet inversion phase method, consisting in the use of a polymer nano-nonwoven as a nonclassic pore precursor. Mechanical properties of the obtained scaffolds were determined, their hydrophilic properties (serum absorbability) were tested, and the content of residues of materials used in the scaffold preparation was determined. Nontoxicity of the developed scaffolds toward T lymphocyte cells was proved. Cultures of primary chondrocytes were obtained successfully. It was proved that an addition of a polymer nano-nonwoven changes the properties of the scaffolds favorably in respect of their subsequent application in tissue engineering.