Fluorimetric determination of gatifloxacin in aqueous, pure and pharmaceutical formulations

摘要

A spectrofluorimetric method was developed for the determination of gatifloxacin. The emission peak for gatifloxacin was recorded at 495nm upon excitation at 291nm. The fluorescence process was pH dependent. The dynamic range for the method was 16-80ng ml(-1)with detection limit of 3.97ng ml(-1). A linear relationship between the fluorescence intensity and the concentration of gatifloxacin solution was obtained with r(2) of 0.9968. The method has successfully applied to the determination of gatifloxacin in pure, authentic and aqueous samples.