Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis The VICTAS Randomized Clinical Trial

Sevransky Jonathan E.; Rothman Richard E.; Hager David N.; Bernard Gordon R.; Brown Samuel M.; Buchman Timothy G.; Busse Laurence W.; Coopersmith Craig M.; DeWilde Christine; Ely Wesley; Eyzaguirre Lindsay M.; Fowler Alpha A.; Gaieski David F.; Gong Michelle N.; Hall Alex; Hinson Jeremiah S.; Hooper Michael H.; Kelen Gabor D.; Khan Akram; Levine Mark A.; Lewis Roger J.; Lindsell Chris J.; Marlin Jessica S.; McGlothlin Anna; Moore Brooks L.; Nugent Katherine L.; Nwosu Samuel; Polito Carmen C.; Rice Todd W.; Ricketts Erin P.; Rudolph Caroline C.; Sanfilippo Fred; Viele Kert; Martin Greg S.; Wright David W.

首页> 外文期刊>JAMA: the Journal of the American Medical Association >Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis The VICTAS Randomized Clinical Trial

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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis The VICTAS Randomized Clinical Trial

机译：维生素C，硫胺素和氢化可源性对肠脓毒症和血管加压症的患者患者的影响 - VICTAS随机临床试验

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IMPORTANCE Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.

机译：脓毒症是一种常见的综合征，发病率和死亡率都很高。维生素C、硫胺素和皮质类固醇的联合治疗被认为是败血症患者的潜在治疗方法。

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《JAMA: the Journal of the American Medical Association 》 |2021年第8期| 共10页
作者
Sevransky Jonathan E.; Rothman Richard E.; Hager David N.; Bernard Gordon R.; Brown Samuel M.; Buchman Timothy G.; Busse Laurence W.; Coopersmith Craig M.; DeWilde Christine; Ely Wesley; Eyzaguirre Lindsay M.; Fowler Alpha A.; Gaieski David F.; Gong Michelle N.; Hall Alex; Hinson Jeremiah S.; Hooper Michael H.; Kelen Gabor D.; Khan Akram; Levine Mark A.; Lewis Roger J.; Lindsell Chris J.; Marlin Jessica S.; McGlothlin Anna; Moore Brooks L.; Nugent Katherine L.; Nwosu Samuel; Polito Carmen C.; Rice Todd W.; Ricketts Erin P.; Rudolph Caroline C.; Sanfilippo Fred; Viele Kert; Martin Greg S.; Wright David W.;
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作者单位

Emory Univ Sch Med Div Pulm Allergy Crit Care &

Sleep Atlanta GA USA;

Johns Hopkins Univ Dept Emergency Med Baltimore MD USA;

Johns Hopkins Univ Div Pulm Crit Care Baltimore MD 21205 USA;

Vanderbilt Univ Med Ctr Div Pulm Crit Care Nashville TN 37235 USA;

Intermt Med Ctr Div Pulm Crit Care Salt Lake City UT USA;

Emory Healthcare Emory Crit Care Ctr Atlanta GA USA;

Emory Univ Sch Med Div Pulm Allergy Crit Care &

Sleep Atlanta GA USA;

Emory Healthcare Emory Crit Care Ctr Atlanta GA USA;

Virginia Commonwealth Univ Div Pulm Crit Care Med Coll Virginia Campus Richmond VA USA;

Vanderbilt Univ Med Ctr Div Pulm Crit Care Nashville TN 37235 USA;

Johns Hopkins Univ Div Brain Injury Outcomes Baltimore MD USA;

Virginia Commonwealth Univ Div Pulm Crit Care Med Coll Virginia Campus Richmond VA USA;

Thomas Jefferson Univ Hosp Dept Emergency Med Philadelphia PA 19107 USA;

Montefiore Med Ctr Dept Crit Care 111 E 210th St Bronx NY 10467 USA;

Emory Univ Dept Emergency Med Atlanta GA 30322 USA;

Johns Hopkins Univ Dept Emergency Med Baltimore MD USA;

Sentara Healthcare Div Pulm Crit Care Norfolk VA USA;

Johns Hopkins Univ Dept Emergency Med Baltimore MD USA;

Oregon Hlth &

Sci Univ Div Pulm Crit Care Portland OR 97201 USA;

NIH Mol &

Clin Nutr Sect Bldg 10 Bethesda MD 20892 USA;

Harbor UCLA Med Ctr Dept Emergency Med Torrance CA 90509 USA;

Vanderbilt Univ Med Ctr Dept Biostat Nashville TN USA;

Vanderbilt Univ Med Ctr Vanderbilt Coordinating Ctr Nashville TN USA;

Berry Consultants LLC Austin TX USA;

Emory Univ Dept Emergency Med Atlanta GA 30322 USA;

Emory Univ Dept Emergency Med Atlanta GA 30322 USA;

Vanderbilt Univ Med Ctr Dept Biostat Nashville TN USA;

Emory Univ Sch Med Div Pulm Allergy Crit Care &

Sleep Atlanta GA USA;

Vanderbilt Univ Med Ctr Div Pulm Crit Care Nashville TN 37235 USA;

Johns Hopkins Univ Dept Emergency Med Baltimore MD USA;

Emory Univ Dept Emergency Med Atlanta GA 30322 USA;

Emory Univ Sch Med Dept Pathol &

Lab Med Atlanta GA 30322 USA;

Berry Consultants LLC Austin TX USA;

Emory Univ Sch Med Div Pulm Allergy Crit Care &

Sleep Atlanta GA USA;

Emory Univ Dept Emergency Med Atlanta GA 30322 USA;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
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2. Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial (vol 322, pg 1476, 2019) [J] . Laterre P-F, Berry S. M., Blemings A. JAMA: the Journal of the American Medical Association . 2019 ,第18期

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3. Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial [J] . Laterre Pierre-Francois, Berry Scott M., Blemings Allan, JAMA: the Journal of the American Medical Association . 2019 ,第15期

机译：Selepressin VS安慰剂对脓毒症休克患者呼吸机和血管加压素的影响：败血症随机临床试验
4. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial [J] . David N. Hager, Michael H. Hooper, Gordon R. Bernard, Trials . 2019 ,第1期

机译：败血症（VICTAS）议定书中的维生素C，硫胺素和类固醇：前瞻性，多中心，双盲，自适应样品大小，随机化，安慰剂控制，临床试验
5. High Dose Vitamin E Supplementation and Mortality: Discussion of the Results of a Meta-analysis of Randomized Controlled Clinical Trial [C] . International Society for Free Radical Research . 2006

机译：高剂量维生素E补充和死亡率：讨论随机对照临床试验的荟萃分析结果
6. Trials and tribulations: Using patients' and physicians' preferences to enhance the efficiency and ethics of randomized clinical trials [D] . Halpern, Scott David 2002

机译：试验和磨难：利用患者和医生的偏好来提高随机临床试验的效率和伦理
7. The Vitamin C Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective multi-center double-blind adaptive sample size randomized placebo-controlled clinical trial [O] . David N. Hager, Michael H. Hooper, Gordon R. Bernard, 2019

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8. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial [O] . David N. Hager, Michael H. Hooper, Gordon R. Bernard, 2019

机译：败血症（VICTAS）议定书中的维生素C，硫胺素和类固醇：前瞻性，多中心，双盲，自适应样品大小，随机化，安慰剂控制，临床试验
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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis The VICTAS Randomized Clinical Trial

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