Development of a new mouse model for coxsackievirus-inducedmyocarditis by attenuating coxsackievirus B3 virulence in the pancreas

Pinkert Sandra; Pryshliak Markian; Pappritz Kathleen; Knoch Klaus; Hazini Ahmet; Dieringer Babette; Schaar Katrin; Dong Fengquan; Hinze Luisa; Lin Jie; Lassner Dirk; Klopfleisch Robert; Solimena Michele; Tschoepe Carsten; Kaya Ziya; El-Shafeey Muhammad; Beling Antje; Kurreck Jens; Van Linthout Sophie; Klingel Karin; Fechner Henry

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Development of a new mouse model for coxsackievirus-inducedmyocarditis by attenuating coxsackievirus B3 virulence in the pancreas

机译：通过在胰腺中衰减CoxSackeivirus B3毒力来开发Coxsackievirus诱导的植物诱导性诱导的胰腺炎

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Aims The coxsackievirus B3 (CVB3) mouse myocarditis model is the standard model for investigation of virus-induced myocarditis but the pancreas, rather than the heart, is the most susceptible organ in mouse. The aim of this study was to develop a CVB3 mouse myocarditis model in which animals develop myocarditis while attenuating viral infection of the pancreas and the development of severe pancreatitis.

机译：目的柯萨奇B3病毒（CVB3）小鼠心肌炎模型是研究病毒性心肌炎的标准模型，但小鼠最易感器官是胰腺，而不是心脏。本研究的目的是建立CVB3小鼠心肌炎模型，在该模型中，动物发生心肌炎，同时减轻胰腺病毒感染和重症胰腺炎的发展。

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来源
《Cardiovascular Research》 |2020年第10期|共11页
作者
Pinkert Sandra; Pryshliak Markian; Pappritz Kathleen; Knoch Klaus; Hazini Ahmet; Dieringer Babette; Schaar Katrin; Dong Fengquan; Hinze Luisa; Lin Jie; Lassner Dirk; Klopfleisch Robert; Solimena Michele; Tschoepe Carsten; Kaya Ziya; El-Shafeey Muhammad; Beling Antje; Kurreck Jens; Van Linthout Sophie; Klingel Karin; Fechner Henry;
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作者单位

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

Charite Univ Med Berlin Campus Virchow Klinikum CVK Berlin Brandenburger Ctr Regenerat Therapies;

Tech Univ Dresden Univ Hosp Carl Gustav Carus Helmholtz Ctr Munich Fac Med Paul Langerhans Inst;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

German Ctr Cardiovasc Res DZHK Partner Site Berlin Charite Oudenarder Str 16 D-13316 Berlin;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

German Ctr Cardiovasc Res DZHK Partner Site Berlin Charite Oudenarder Str 16 D-13316 Berlin;

Inst Kardiale Diagnost &

Therapie IKDT Moltkestr 31 D-12203 Berlin Germany;

Free Univ Berlin Inst Vet Pathol Kaiserswerther Str 16-18 D-14195 Berlin Germany;

Tech Univ Dresden Univ Hosp Carl Gustav Carus Helmholtz Ctr Munich Fac Med Paul Langerhans Inst;

Charite Univ Med Berlin Dept Cardiol Campus Virchow Klinikum CVK Charitepl 1 D-10117 Berlin;

Heidelberg Univ Dept Med 3 D-69120 Heidelberg Germany;

Charite Univ Med Berlin Campus Virchow Klinikum CVK Berlin Brandenburger Ctr Regenerat Therapies;

Charite Univ Med Berlin Virchowweg 6 D-10117 Berlin Germany;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

Charite Univ Med Berlin Campus Virchow Klinikum CVK Berlin Brandenburger Ctr Regenerat Therapies;

Univ Hosp Tuebingen Inst Pathol &

Neuropathol Cardiopathol Liebermeisterstr 8 D-72076 Tubingen;

Tech Univ Berlin Inst Biotechnol Dept Appl Biochem Gustav Meyer Allee 25 D-15533 Berlin Germany;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
CoxsackievirusB3; Pancreatitis; Myocarditis; Mouse model; Intravenous; Intraperitoneal; Inflammation; Virus; Heart; Pancreas; icroRNA target sites;

机译：Coxsackievirus B3;胰腺炎;心肌炎;小鼠模型;静脉注射;腹膜内;炎症;病毒;心脏;胰腺;microRNA靶位点;

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1. Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases [J] . Kidsadagon Pringproa, Anucha Sathanawongs, Chananthida Khamphilai, 中国神经再生研究（英文版） . 2016,第010期
2. Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway [J] . Zheng LI, Qian-qian MA, Yan YAN, 中国药理学报：英文版 . 2016,第010期
3. Improvement of the Coxsackievirus B3 (CVB3)-induced mice-myocarditis model by development of a pancreas-attenuated virus [J] . Pryshliak M., Pinkert S., Hazini A., Human gene therapy . 2016,第11期

机译：通过开发胰腺减毒病毒改善柯萨奇病毒B3（CVB3）诱导的小鼠心肌炎模型
4. Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants. [J] . Groarke JM, Pevear DC The Journal of Infectious Diseases . 1999,第6期

机译：抵抗耐普康奈尔的柯萨奇病毒B3变体的毒性减弱。
5. EXPRESSION AND DISTRIBUTION OF THE RECEPTORS FOR COXSACKIEVIRUS B3 DURING FETAL DEVELOPMENT OF THE BALB/C MOUSE AND OF THEIR BRAIN CELLS IN CULTURE [J] . Xu RL, Crowell RL Virus Research: An International Journal of Molecular and Cellular Virology . 1996,第1a2期

机译：胎儿在BALB / C小鼠及其脑细胞发育过程中柯萨奇病毒B3受体的表达和分布。
6. Computational analysis of the synonymous codon usage bias in human coxsackievirus B3 strain 28 [C] . Quek Albert, Sim-Hui Tee 2013 IEEE Business Engineering and Industrial Applications Colloquium . 2013

机译：人柯萨奇病毒B3株28同义密码子使用偏倚的计算分析
7. Detecting Novel Structural Interactions within the Coxsackievirus B3 Genomic RNA Using Experimental and Computational Approaches [D] . Horn, Christopher M. 2019

机译：使用实验和计算方法检测柯萨奇病毒B3基因组RNA中的新型结构相互作用。
8. Coxsackievirus B3 Engineered To Contain MicroRNA Targets for Muscle-Specific MicroRNAs Displays Attenuated Cardiotropic Virulence in Mice [O] . Feng He, Hailan Yao, Jianmin Wang, 2015

机译：柯萨奇病毒B3被设计为包含针对特定肌肉的MicroRNA的MicroRNA靶标可降低小鼠的心肌毒性。
9. Coxsackievirus B3 Engineered To Contain MicroRNA Targets for Muscle-Specific MicroRNAs Displays Attenuated Cardiotropic Virulence in Mice [O] . Feng He, Hailan Yao, Jianmin Wang, 2015

机译：Coxsackievirus B3设计用于含有特定肌肉的MicroRNA的MicroRNA靶标显示老鼠中的减毒的蠕动毒力
10. Coxsackievirus B3: Primary Structure of the 5' Non-Coding and Capsid Protein-Coding Regions of the Genome [R] . Tracy, S., Liu, H. L., Chapman, N. M. 1985

机译：柯萨奇病毒B3：基因组5'非编码和衣壳蛋白编码区的一级结构

Development of a new mouse model for coxsackievirus-inducedmyocarditis by attenuating coxsackievirus B3 virulence in the pancreas

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