Delineating the molecular and histological events that govern right ventricular recovery using a novelmouse model of pulmonary artery de-banding

摘要

Aims The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated pressure overload is unknown. We sought to establish a novel mouse model of gradual RV recovery from pressure overload and use it to delineate RV reverse-remodelling events.