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Cellular MM icrobiology: The metabolic interface between host cell and pathogen

机译：微生物学：微生物学：宿主细胞和病原体之间的代谢界面

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Abstract >Cellular Microbiology has benefited greatly from the use of immortalized cell lines as host cells for tissue culture models of infection. However, these cells lack many important characteristics of the different cell lineages that are found in vivo. This deficiency is particularly true of macrophages that we now know derive from several distinct ontogenic lineages. This perspective discusses these challenges and possible approaches to overcome them. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type=“main”xml:lang=“en”><title type=“main”>abstract>使用永生化细胞系作为感染组织培养模型的宿主细胞，使细胞微生物学受益匪浅。然而，这些细胞缺乏体内发现的不同细胞谱系的许多重要特征。这种缺陷尤其适用于巨噬细胞，我们现在知道这些巨噬细胞来源于几个不同的个体发生谱系。本观点讨论了这些挑战以及克服这些挑战的可能方法 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Russell David G.&option=202" target="_blank" rel="nofollow">Russell David G.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Microbiology and Immunology College of Veterinary MedicineCornell UniversityIthaca NY USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_molecular-plants-english-version_thesis/0201230683288.html">An Arabidopsis Lipid Flippase Is Required for Timely Recruitment of Defenses to the Host-Pathogen Interface at the Plant Cell Surface</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=William Underwood&option=202" target="_blank" rel="nofollow" class="tuijian_auth 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altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant</a> <b>[P]</b> . <span> 外国专利：  PL209786B1 </span> <span> . 2011-10-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含Fc区的母体多肽的变体，具有Fcγ受体结合（Fc R）亲和力改变的Fc区变体的多肽，具有Fcγ新生受体结合（Fc Rn）亲和力改变的Fc区的多肽，组成核酸，载体，宿主细胞，获得多肽变体的方法，其用途和获得区域Fc变体的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130415027007.html">Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcγR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant</a> <b>[P]</b> . <span> 外国专利：  PL220113B1 </span> <span> . 2015-08-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含Fc区的亲本多肽的变体，包含具有Fcγ受体（FcγR）结合亲和力改变的Fc区变体的多肽，包含具有新生Fc受体（FcRn）结合亲和力改变的Fc区变体的多肽，组成，分离的核酸，载体，宿主细胞，多肽变体的制备方法，多肽变体的用途和Fc区变体的制备方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130425339255.html">Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant</a> <b>[P]</b> . <span> 外国专利：  PL394232A1 </span> <span> . 2011-07-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含Fc区的亲本多肽的变体，包含具有Fcγ受体（FcR）的结合亲和力改变的Fc区的变体的多肽，包含具有新生Fc受体（FcRn）的结合亲和力改变的Fc区的变体的多肽，组成，分离的核酸，载体，宿主细胞，多肽变体的制备方法，多肽变体的用途和Fc区变体的制备方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" 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