• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular microbiology >Emerging concepts in the pathogenesis of the Streptococcus pneumoniaeStreptococcus pneumoniae : From nasopharyngeal colonizer to intracellular pathogen
【24h】

Emerging concepts in the pathogenesis of the Streptococcus pneumoniaeStreptococcus pneumoniae : From nasopharyngeal colonizer to intracellular pathogen

机译：在肺炎链球菌肺炎链球菌的发病机制中的新兴概念肺炎链球菌肺炎：从鼻咽结肠器到细胞内病原体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract > Streptococcus pneumoniae (the pneumococcus) is a human respiratory tract pathogen and a major cause of morbidity and mortality globally. Although the pneumococcus is a commensal bacterium that colonizes the nasopharynx, it also causes lethal diseases such as meningitis, sepsis, and pneumonia, especially in immunocompromised patients, in the elderly, and in young children. Due to the acquisition of antibiotic resistance and the emergence of nonvaccine serotypes, the pneumococcus has been classified as one of the priority pathogens for which new antibacterials are urgently required by the World Health Organization, 2017. Understanding molecular mechanisms behind the pathogenesis of pneumococcal infections and bacterial interactions within the host is crucial to developing novel therapeutics. Previously considered to be an extracellular pathogen, it is becoming evident that pneumococci may also occasionally establish intracellular niches within the body to escape immune surveillance and spread within the host. Intracellular survival within host cells also enables pneumococci to resist many antibiotics. Within the host cell, the bacteria exist in unique vacuoles, thereby avoiding degradation by the acidic lysosomes, and modulate the expression of its virulence genes to adapt to the intracellular environment. To invade and survive intracellularly, the pneumococcus utilizes a combination of virulence factors such as pneumolysin (PLY), pneumococcal surface protein A (PspA), pneumococcal adhesion and virulence protein B (PavB), the pilus‐1 adhesin RrgA, pyruvate oxidase (SpxB), and metalloprotease (ZmpB). In this review, we discuss recent findings showing the intracellular persistence of Streptococcus pneumoniae and its underlying mechanisms. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>肺炎链球菌是一种人类呼吸道病原体，是全球发病率和死亡率的主要原因。尽管肺炎球菌是一种寄生于鼻咽的共生细菌，但它也会导致致命疾病，如脑膜炎、败血症和肺炎，尤其是免疫功能低下的患者、老年人和幼儿。由于获得抗生素耐药性和非疫苗血清型的出现，肺炎球菌已被列为优先病原体之一，世界卫生组织2017年迫切需要新的抗菌药物。了解肺炎球菌感染发病机制背后的分子机制和宿主内的细菌相互作用对于开发新的治疗方法至关重要。以前被认为是一种细胞外病原体，现在越来越明显的是，肺炎球菌偶尔也会在体内建立细胞内生态位，以逃避免疫监视并在宿主内传播。宿主细胞内的细胞存活也使肺炎球菌能够抵抗多种抗生素。在宿主细胞内，细菌存在于独特的液泡中，从而避免酸性溶酶体的降解，并调节其毒力基因的表达以适应细胞内环境。为了侵入细胞并在细胞内存活，肺炎球菌利用多种毒力因子的组合，如溶血素（PLY）、肺炎球菌表面蛋白a（PspA）、肺炎球菌粘附和毒力蛋白B（PavB）、菌毛1粘附素RrgA、丙酮酸氧化酶（SpxB）和金属蛋白酶（ZmpB）。在这篇综述中，我们讨论了显示肺炎链球菌在细胞内持续存在的最新发现及其潜在机制 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Subramanian Karthik&option=202" target="_blank" rel="nofollow">Subramanian Karthik;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Henriques‐Normark Birgitta&option=202" target="_blank" rel="nofollow">Henriques‐Normark Birgitta;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Normark Staffan&option=202" target="_blank" rel="nofollow">Normark Staffan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm Sweden;</p> <p>Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm Sweden;</p> <p>Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm Sweden;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=immunity&option=203" rel="nofollow">immunity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intracellular survival&option=203" rel="nofollow">intracellular survival;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pathogenesis&option=203" rel="nofollow">pathogenesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=persistence&option=203" rel="nofollow">persistence;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pneumococci&option=203" rel="nofollow">pneumococci;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Streptococcus pneumoniae&option=203" rel="nofollow">Streptococcus pneumoniae;</a> </p> <div class="translation"> 机译：免疫;细胞内存活;发病机制;持续存在;肺炎球菌;链球菌肺炎; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_biomedical-environmental-sciences_thesis/0201222065805.html">A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=XIE Na&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">XIE Na,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SHAO Zhu Jun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">SHAO Zhu Jun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CHEN Zhao Yun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">CHEN Zhao Yun,</a> <a href="/journal-foreign-5748/" target="_blank" rel="nofollow" class="tuijian_authcolor">生物医学与环境科学（英文版） .</a> <span>2018</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_asia-pacific-tropical-biomedical-journal-english_thesis/0201254086307.html">Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Belay Anagaw&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Belay Anagaw,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chandrashekhar Unakal&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chandrashekhar Unakal,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mucheye Gezachew&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mucheye Gezachew,</a> <a href="/journal-foreign-15935/" target="_blank" rel="nofollow" class="tuijian_authcolor">亚太热带生物医学杂志（英文版） .</a> <span>2013</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-medical-journal_thesis/0201254450731.html">Serological and molecular capsular typing, antibiotic susceptibility and multilocus sequence typing of Streptococcus pneumoniae isolates from invasive and non-invasive infections</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ZHANG Yi-jie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">ZHANG Yi-jie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CHEN Yu-shen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">CHEN Yu-shen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=WANG Zhan-wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">WANG Zhan-wei,</a> <a href="/journal-foreign-6708/" target="_blank" rel="nofollow" class="tuijian_authcolor">中华医学杂志（英文版） .</a> <span>2013</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023145551.html">Ecthyma gangrenosum caused by Klebsiella pneumoniae Klebsiella pneumoniae and Streptococcus vestibularis Streptococcus vestibularis in a patient with acute myeloid leukemia: an emerging pathogen</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Koumaki Dimitra&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Koumaki Dimitra,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Koumaki Vasiliki&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Koumaki Vasiliki,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Katoulis Alexander C.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Katoulis Alexander C.,</a> <a href="/journal-foreign-22371/" target="_blank" rel="nofollow" class="tuijian_authcolor">International journal of dermatology .</a> <span>2019</span><span>,第4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Ecthyma gangrenosum由Klebsiella Pneumoniae Klebsiella肺炎和孢子菌位于患有急性髓性白血病的患者的患者中肺炎链球菌和孢子菌链球菌：一种新兴病原体</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/07040220119.html">Genome research: Evolution of Streptococcus pneumoniae - What is a pathogen? [Evolution von Streptococcus pneumoniae - Was ist ein Pathogen?]</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brückner R.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Brückner R.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Denapaite D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Denapaite D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Henrich B.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Henrich B.,</a> <a href="/journal-foreign-14952/" target="_blank" rel="nofollow" class="tuijian_authcolor">Biospektrum .</a> <span>2010</span><span>,第7期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基因组研究：肺炎链球菌的进化-什么是病原体？ [进化性肺炎链球菌-是病原菌吗？]</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020141104.html">The impact of the ancillary pilus‐1 protein RrgA of Streptococcus pneumoniae Streptococcus pneumoniae on colonization and disease</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Iovino Federico&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Iovino Federico,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nannapaneni Priyanka&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nannapaneni Priyanka,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Henriques‐Normark Birgitta&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Henriques‐Normark Birgitta,</a> <a href="/journal-foreign-27937/" target="_blank" rel="nofollow" class="tuijian_authcolor">Molecular Microbiology .</a> <span>2020</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肺炎链球菌肺炎链球菌肺炎链球菌对殖民化和疾病的影响</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-201130_thesis/0705011243132.html">Household air pollution exposure and nasopharyngeal carriage of streptococcus pneumoniae in Malawian infants</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=R. Chartier&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">R. Chartier,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M. Dherani&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">M. Dherani,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=T. Tafatatha&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">T. Tafatatha,</a> <a href="/conference-foreign-201130/" target="_blank" rel="nofollow" class="tuijian_authcolor">Annual conference of the International Society of Exposure Science .</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在马拉维婴儿的肺炎链球菌的家用空气污染暴露和鼻咽地托运</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061702357.html">The role of cytosolic access in Streptococcus pneumoniae nasopharyngeal colonization</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lemon, Jamie K.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lemon, Jamie K. </a> <span>2015</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：胞浆通路在肺炎链球菌鼻咽定植中的作用</span> </p> </li> <li> <div> <b>9. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040001068938.html">A Capsular Polysaccharide-Specific Antibody Alters Streptococcus pneumoniae Gene Expression during Nasopharyngeal Colonization of Mice</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Christopher R. Doyle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Christopher R. Doyle,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jee-Young Moon&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jee-Young Moon,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Johanna P. Daily&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Johanna P. Daily,</a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：荚膜多糖特异性抗体改变小鼠鼻咽殖民化过程中肺炎链球菌基因表达。</span> </p> </li> <li> <div> <b>10. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000131574268.html">Emerging concepts in the pathogenesis of theStreptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Karthik Subramanian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Karthik Subramanian,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Birgitta Henriques‐Normark&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Birgitta Henriques‐Normark,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Staffan Normark&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Staffan Normark </a> <span>2019</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新兴概念在TheStreptocccus肺炎群发病机制中：从鼻咽结肠器到细胞内病原体</span> </p> </li> <li> <div> <b>11. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/02071108494.html">Streptococcus pneumoniae Biofilm Formation Is Strain Dependent, Multifactorial, and Associated with Reduced Invasiveness and Immunoreactivity during Colonization.</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Blanchette-Cain, K.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Blanchette-Cain, K.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Hinojosa, C. A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Hinojosa, C. A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Babu, R. A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Babu, R. A.,</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肺炎链球菌生物膜形成是菌株依赖性，多因素，并且与定殖期间的侵入性和免疫反应性降低相关。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201298136430.html">Penicillin Resistance in Nasopharyngeal Streptococcus pneumoniae among Children with Sickle Cell Disease Immunized with 7-Valent Pneumococcal Conjugate Vaccine</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Patricia Belintani Blum Fonseca&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Patricia Belintani Blum Fonseca</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Calil Kairalla Farhat&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Calil Kairalla Farhat</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Regina Celia de Menezes Succi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Regina Celia de Menezes Succi</a> <span> <a href="/journal-cn-56464/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 疫苗（英文） </a> </span> <span> . 2013</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201297905572.html">Prevalence and Antimicrobial Susceptibility Pattern of Streptococcus pneumoniae at General Hospital in the Central Region of Japan from December 2013 to February 2014</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Masaaki Minami&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Masaaki Minami</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ryoko Sakakibara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Ryoko Sakakibara</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Taichi Imura&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Taichi Imura</a> <span> <a href="/journal-cn-56593/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物科学与医学（英文） </a> </span> <span> . 2014</span><span>,第6期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-23164_thesis/02022811050.html">Interaction between Streptococcus pneumoniae and human lung cells in an acute tissue infection model</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Feng Xu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Feng Xu</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HuahaoShen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,HuahaoShen</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klaus Dalhoff&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Klaus Dalhoff</a> <span> <a href="/conference-cn-23164/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2006年浙江省医学会呼吸系病年会 </a> <span> <span> . 2006</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203877138.html">针对肺炎链球菌(Streptococcus pneumoniae)血清型8的疫苗</a> <b>[P]</b> . <span> 中国专利： CN106879257B </span> <span> . 2020.08.11</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202963671.html">针对肺炎链球菌（Streptococcus Pneumoniae）的疫苗和组合物</a> <b>[P]</b> . <span> 中国专利： CN103501809B </span> <span> . 2018.08.10</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130444368325.html">THE USE OF BACTERIAL SHUFFLED AND CHIMERIC PHAGE ASSOCIATED LYTIC ENZYMES FOR THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF COLONIZATION AND INFECTIONS CAUSED BY STREPTOCOCCUS PNEUMONIAE</a> <b>[P]</b> . <span> 外国专利： <!-- --> AU2002336752A1 </span> <span> . 2003-04-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：细菌融合和嵌合噬菌体相关溶菌酶在肺炎链球菌引起的定殖和感染性结肠炎和感染性治疗中的应用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130444442019.html">Recombinant DNA comprising the green fluorescent protein gene, useful e.g. to determine colonization capacity of bacteria, includes the mal operon of Streptococcus pneumoniae</a> <b>[P]</b> . <span> 外国专利： <!-- --> ES2184568A1 </span> <span> . 2003-04-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含绿色荧光蛋白基因的重组DNA，例如确定细菌的定殖能力，包括肺炎链球菌的恶意操纵子 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130444443867.html">Recombinant DNA comprising the green fluorescent protein gene, useful e.g. to determine colonization capacity of bacteria, includes the mal operon of Streptococcus pneumoniae</a> <b>[P]</b> . <span> 外国专利： <!-- --> ES2182628A1 </span> <span> . 2003-03-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含绿色荧光蛋白基因的重组DNA，例如确定细菌的定殖能力，包括肺炎链球菌的恶意操纵子 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028329244','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche"> <!-- <a href="javascript:void(0);" onclick="link_analysis('/shoppingcart/auth/list.html',this)">购物车</a>--> </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704028329244down" data-source="7," data-out-id="z3ROYiskdkPI6zU35xJKe7ANHEe5ZuW93dksP+QkD7zKjkN8VUseABQ9kKvPoLVF," data-f-source-id="7" data-title="Emerging concepts in the pathogenesis of the <i >Streptococcus pneumoniaeStreptococcus pneumoniae : From nasopharyngeal colonizer to intracellular pathogen" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="15891" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Emerging concepts in the pathogenesis of the <i >Streptococcus pneumoniaeStreptococcus pneumoniae : From nasopharyngeal colonizer to intracellular pathogen"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>