Molecular interactions between        <i >Neisseria meningitidisNeisseria meningitidis        and its human host

Coureuil Mathieu; Jamet Anne; Bille Emmanuelle; Lécuyer Hervé; Bourdoulous Sandrine; Nassif Xavier

摘要

Abstract > Neisseria meningitidis is a Gram‐negative bacterium that asymptomatically colonises the nasopharynx of humans. For an unknown reason, N .? meningitidis can cross the nasopharyngeal barrier and invade the bloodstream where it becomes one of the most harmful extracellular bacterial pathogen. This infectious cycle involves the colonisation of two different environments. (a) In the nasopharynx, N .? meningitidis grow on the top of mucus‐producing epithelial cells surrounded by a complex microbiota. To survive and grow in this challenging environment, the meningococcus expresses specific virulence factors such as polymorphic toxins and MDAΦ. (b) Meningococci have the ability to survive in the extra cellular fluids including blood and cerebrospinal fluid. The interaction of N .? meningitidis with human endothelial cells leads to the formation of typical microcolonies that extend overtime and promote vascular injury, disseminated intravascular coagulation, and acute inflammation. In this review, we will focus on the interplay between N .? meningitidis and these two different niches at the cellular and molecular level and discuss the use of inhibitors of piliation as a potent therapeutic approach. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type=“main”xml:lang=“en”><title type=“main”>摘要>脑膜炎奈瑟菌是一种革兰氏阴性细菌，无症状地在人类鼻咽部结殖。不知什么原因，N 脑膜炎可以穿过鼻咽屏障，侵入血液，成为最有害的细胞外细菌病原体之一。这种传染循环涉及两种不同环境的定植。（a）在鼻咽，N 脑膜炎生长在分泌粘液的上皮细胞顶部，周围有复杂的微生物群。为了在这种充满挑战的环境中生存和生长，脑膜炎球菌表达特定的毒力因子，如多形性毒素和丙二醛。（b）脑膜炎球菌能够在包括血液和脑脊液在内的细胞外液体中存活。N的相互作用人类内皮细胞的脑膜炎会导致典型的微菌落形成，这些微菌落会延长时间，促进血管损伤、弥散性血管内凝血和急性炎症。在这篇综述中，我们将重点讨论N之间的相互作用脑膜炎以及细胞和分子水平上的这两个不同的生态位，并讨论作为有效治疗方法的菌毛抑制剂的使用 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Coureuil Mathieu&option=202" target="_blank" rel="nofollow">Coureuil Mathieu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jamet Anne&option=202" target="_blank" rel="nofollow">Jamet Anne;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bille Emmanuelle&option=202" target="_blank" rel="nofollow">Bille Emmanuelle;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lécuyer Hervé&option=202" target="_blank" rel="nofollow">Lécuyer Hervé;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bourdoulous Sandrine&option=202" target="_blank" rel="nofollow">Bourdoulous Sandrine;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nassif Xavier&option=202" target="_blank" rel="nofollow">Nassif Xavier;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>InsermInstitut Necker Enfants MaladesU1151 Paris France;</p> <p>InsermInstitut Necker Enfants MaladesU1151 Paris France;</p> <p>InsermInstitut Necker Enfants MaladesU1151 Paris France;</p> <p>InsermInstitut Necker Enfants MaladesU1151 Paris France;</p> <p>Université de ParisUMR_S 1151 Paris France;</p> <p>InsermInstitut Necker Enfants MaladesU1151 Paris France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_biomedical-environmental-sciences_thesis/0201222116856.html">Molecular Characteristics of Neisseria meningitidis Isolated during an Outbreak in a Jail: Associatition with the Spread and Distributition of ST-4821 Complex Serogroup C Cltione in China</a> <b>[J]</b> . <span> <a 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auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：致命的脑膜炎球菌脑膜脑膜脑膜脑膜脑膜脑膜炎症患者由Serogroup C Neisseria Meningitis属于ST-4821复合物</span> </p> </li> <li> <div> <b>9. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/0206138626.html">Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ingrey, Keely.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ingrey, Keely. </a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：脑膜炎奈瑟氏球菌中假定的血红素ABC转运蛋白的鉴定和分子表征。</span> </p> </li> <li> <div> <b>10. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040001067226.html">Serogroup-Specific 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Steven Seifert&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">H. Steven Seifert </a> <span>2011</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：与宿主细胞的相互作用导致脑膜炎奈瑟菌菌毛脱落</span> </p> </li> <li> <div> <b>12. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/020711556976.html">Heterogeneity of Molecular Size and Antigenic Expression within Lipooligosaccharides of Individual Strains of Neisseria gonorrhoeae and Neisseria meningitidis</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schneider, H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schneider, H.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hale, T. L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hale, T. L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zollinger, W. D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zollinger, W. D.,</a> <span>1984</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：淋病奈瑟菌和脑膜炎奈瑟球菌个别低脂寡糖的分子大小和抗原表达的异质性</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201298269570.html">Surface adhesion and host response as pathogenicity factors of Neisseria meningitidis</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jose Uberos&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Jose Uberos</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M Molina-Oya&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,M Molina-Oya</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=S Martinez-Serrano&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,S Martinez-Serrano</a> <span> <a href="/journal-cn-57565/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界临床传染病学杂志 </a> </span> <span> . 2015</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-23164_thesis/02022811050.html">Interaction between Streptococcus pneumoniae and human lung cells in an acute tissue infection model</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Feng Xu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Feng Xu</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HuahaoShen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,HuahaoShen</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klaus Dalhoff&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Klaus Dalhoff</a> <span> <a href="/conference-cn-23164/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2006年浙江省医学会呼吸系病年会 </a> <span> <span> . 2006</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312375790.html">Molecular Cloning of the Rhyzopertha Dominica and Antennal Sensilla of Sitophilus Granarius,Tribolium Castaneum and Their Host Range</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SULIMAN ABDALLA IBRAHIM ALI&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . SULIMAN ABDALLA IBRAHIM ALI</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120255267.html">脑膜炎奈瑟氏球菌(Neisseria meningitidis)的多核苷酸和多肽BASB033及其用途</a> <b>[P]</b> . <span> 中国专利： CN1245419C </span> <span> . 2006.03.15</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120104521337.html">脑膜炎奈瑟氏球菌(Neisseria meningitidis)的多核苷酸和多肽BASB033及其用途</a> <b>[P]</b> . <span> 中国专利： CN1326508A </span> <span> . 2001-12-12</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130449103379.html">Vaccine composition, processes for immunization against neisseria gonorrhoeae and to prepare a vaccine composition, isolated and purified DNA sequence, plasmid, host cell, process for producing a chimeric recombinant pilin protein from neisseria gonorrhoeae and neisseria meningitidis, chimeric recombinant protein isolated and purified from neisseria gonorhoeae and neisseria meningitidis, and, process for immunization against neisseria muningitidis</a> <b>[P]</b> . <span> 外国专利：  BR9910005A </span> <span> . 2001-01-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疫苗组合物，针对淋病奈瑟氏球菌的免疫方法以及制备疫苗组合物，分离和纯化的DNA序列，质粒，宿主细胞，从淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌生产嵌合重组菌毛蛋白的方法，从奈瑟氏球菌分离和纯化的嵌合重组蛋白淋病奈瑟菌和脑膜炎奈瑟氏球菌，以及针对慕尼黑菌的免疫接种方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130435168435.html">Neisseria meningitidis LbpB protein coding polynucleotides, protein fragment or a protein featuring specific sameness with the Neisseria meningitidis LbpB protein, a host cell containing such polynucleotide and method for its production, methods for the p</a> <b>[P]</b> . <span> 外国专利：  PL194800B1 </span> <span> . 2007-07-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：脑膜炎奈瑟氏球菌LbpB蛋白编码的多核苷酸，蛋白片段或具有与脑膜炎奈瑟氏球菌LbpB蛋白特异性相同的蛋白质的片段，含有该多核苷酸的宿主细胞及其生产方法，p方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130409431203.html">pencicillin-binding protein, nucleic acid, antibody or antibody fragment, medicament, pharmaceutical composition, uses of at least one penicillin-binding protein or fragment or variant or fragment thereof, of at least one nucleic acid and of at least one antibody or antibody fragment, in vitro antibody detection methods directed against neisseria meningitidis infection from a penicillin-binding protein, nucleic acid, antibody or an antibody fragment, pharmaceutical composition of at least one penicillin-binding protein or fragment or variant or variant thereof, of at least one nucleic acid and at least one antibody directed against neisseria meningitidis infection from a biological sample of a mammal and in vitro diagnosis of neisseria miningitidis infection from a biological sample from a mammal and monoclonal antibody</a> <b>[P]</b> . <span> 外国专利：  BRPI0610802A2 </span> <span> . 2016-11-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：青霉素结合蛋白，核酸，抗体或抗体片段，药物，药物组合物，至少一种青霉素结合蛋白或其片段或变异体或片段，至少一种核酸和至少一种抗体或抗体片段的用途，针对脑膜炎奈瑟菌的青霉素结合蛋白，核酸，抗体或抗体片段感染的体外抗体检测方法，至少一种青霉素结合蛋白或其片段或变异体或变异体，至少一种核酸的药物组合物酸和至少一种针对哺乳动物生物样品中脑膜炎奈瑟氏菌感染的抗体以及来自哺乳动物生物样品中的矿业性奈瑟氏球菌感染的体外诊断和单克隆抗体 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" 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Molecular interactions between Neisseria meningitidisNeisseria meningitidis and its human host

摘要