The assembly of glycosphingolipid determines their immunomodulatory effect: A novel method for structure-based design of immunotherapy

Adar Tomer; Lankalapalli Ravi Shankar; Bittman Robert; Ilan Yaron

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The assembly of glycosphingolipid determines their immunomodulatory effect: A novel method for structure-based design of immunotherapy

机译：糖磷脂的组装决定了它们的免疫调节作用：一种基于结构的免疫疗法设计的新方法

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摘要

Structure-activity relationships provide insight into the binding interactions of beta-glycosphingolipids (GSLs) with both the TCR and the CD1d molecules, as well as the subsequent immunologic response of regulatory NKT cells. A

机译：结构-活性关系为深入了解β-鞘糖脂（GSL）与TCR和CD1d分子的结合相互作用，以及随后调节性NKT细胞的免疫反应提供了依据。A.

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来源
《Cellular immunology》 |2020年第1期|共8页
作者
Adar Tomer; Lankalapalli Ravi Shankar; Bittman Robert; Ilan Yaron;
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作者单位

Hadassah Hebrew Univ Med Ctr Dept Med Jerusalem Israel;

CUNY Dept Chem &

Biochem Queens Coll New York NY USA;

CUNY Dept Chem &

Biochem Queens Coll New York NY USA;

Hadassah Hebrew Univ Med Ctr Dept Med Jerusalem Israel;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Glycosphingolipids; Immune mediated hepatitis; NKT cells;

机译：糖磷脂;免疫介导的肝炎;NKT细胞;

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The assembly of glycosphingolipid determines their immunomodulatory effect: A novel method for structure-based design of immunotherapy

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