Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms

Qaradakhi Tawar; Matsoukas Minos Timotheos; Hayes Alan; Rybalka Emma; Caprnda Martin; Rimarova Kvetoslava; Sepsi Milan; Busselberg Dietrich; Kruzliak Peter; Matsoukas John; Apostolopoulos Vasso; Zulli Anthony

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Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms

机译：Alamandine通过PKA依赖性机制逆转过量抑制血管血症诱导的血管功能障碍

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IntroductionHyperhomocysteinemia (HHcy) impairs nitric oxide endothelium-dependent vasodilation, consequently leading to atherosclerosis, a risk factor for cardiovascular disease. Novel treatments for HHcy are necessary.

机译：简介高同型半胱氨酸血症（HHcy）损害一氧化氮内皮依赖性血管舒张功能，从而导致动脉粥样硬化，这是心血管疾病的危险因素。HHcy的新疗法是必要的。

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来源
《Cardiovascular therapeutics》 |2017年第6期|共11页
作者
Qaradakhi Tawar; Matsoukas Minos Timotheos; Hayes Alan; Rybalka Emma; Caprnda Martin; Rimarova Kvetoslava; Sepsi Milan; Busselberg Dietrich; Kruzliak Peter; Matsoukas John; Apostolopoulos Vasso; Zulli Anthony;
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作者单位

Victoria Univ Coll Hlth &

Biomed Ctr Chron Dis Melbourne Vic Australia;

Univ Patras Dept Pharm Patras Greece;

Victoria Univ Coll Hlth &

Biomed Ctr Chron Dis Melbourne Vic Australia;

Victoria Univ Coll Hlth &

Biomed Ctr Chron Dis Melbourne Vic Australia;

Comenius Univ Dept Internal Med 2 Fac Med Bratislava Slovakia;

Pavol Jozef Safarik Univ Dept Publ Hlth &

Hyg Fac Med Kosice Slovakia;

Univ Hosp Dept Internal Med &

Cardiol Brno Czech Republic;

Weill Cornell Med Coll Qatar Qatar Fdn Educ City Dept Physiol &

Biophys Doha Qatar;

Univ Vet &

Pharmaceut Sci Dept Chem Drugs Fac Pharm Brno Czech Republic;

ELdrug SA Patras Sci Pk Patras Greece;

Victoria Univ Coll Hlth &

Biomed Ctr Chron Dis Melbourne Vic Australia;

Victoria Univ Coll Hlth &

Biomed Ctr Chron Dis Melbourne Vic Australia;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Alamandine; Endothelial dysfunction; Homocysteine; MrgD; Protein kinase A;

机译：Alamandine;内皮功能障碍;同性恋;MRGD;蛋白激酶a;

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5. Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms [J] . Qaradakhi Tawar, Matsoukas Minos Timotheos, Hayes Alan, Cardiovascular therapeutics . 2017,第6期

机译：Alamandine通过PKA依赖性机制逆转高管抑制血管血症诱导的血管功能障碍
6. Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction - Possible dysregulation of phosphatidylinositol-3-kinase and its downstream phosphoinositide dependent kinase and protein kinase B [J] . SharmaS., SinghM., SharmaP.L. European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：高同型半胱氨酸血症引起的血管内皮功能障碍的机制-磷脂酰肌醇3激酶及其下游磷酸肌醇依赖性激酶和蛋白激酶B可能失调
7. Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction - Possible dysregulation of phosphatidylinositol-3-kinase and its downstream phosphoinositide dependent kinase and protein kinase B [J] . SharmaS., SinghM., SharmaP.L. European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：高同型半胱氨酸血症引起的血管内皮功能障碍的机制-磷脂酰肌醇3激酶及其下游磷酸肌醇依赖性激酶和蛋白激酶B可能失调
8. Vascular dysfunction and autonomic failure are associated in a porcine model of septic shock and resuscitation [C] . Carrara M, A Herpain, G Baselli, Conference of the European Study Group on Cardiovascular Oscillations . 2020

机译：在感染性休克和复苏的猪模型中，血管功能障碍和自主神经功能衰竭相关
9. Cytochrome P450 derived oxylipids induce vascular barrier dysfunction in an oxidative stress dependent mechanism [D] . Mavangira, Vengai. 2016

机译：细胞色素P450衍生的奥氧基哌脂诱导氧化应激依赖性机理中的血管阻隔功能障碍
10. Vascular Protection of TPE-CA on Hyperhomocysteinemia-induced Vascular Endothelial Dysfunction through AA Metabolism Modulated CYPs Pathway [O] . Hui Li, Zhenli Liu, Linlin Liu, 2019

机译：TPE-CA通过AA代谢调节CYPs途径对高同型半胱氨酸血症诱导的血管内皮功能障碍的血管保护作用
11. Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms [O] . Qaradakhi T, Matsoukas MT, Hayes Alan, 2017

机译：alamandine通过pKa依赖性机制逆转高同型半胱氨酸血症诱导的血管功能障碍
12. NF1 Signal Transduction and Vascular Dysfunction. [R] . Pumiglia, K. 2015

机译：NF1信号转导和血管功能障碍。

Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms

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