The feasibility of using infrared spectroscopy for the real-time, in situ analysis of resin-bound photocleavable linkers from a single bead is illustrated using infrared microscopy. Results indicate this technique to be an extremely powerful tool for the analysis of photocleavage reactions directly on the solid-phase support, This report further details methodology providing very high degree of automation to eliminate many of the sampling problems associated with batch analysis.
展开▼
