Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage | Bentham Science

摘要

Background and Objectives: The relationship between vascular damage and diabetesmellitus was exploited using avocado seed extracts. The purpose of the study was to understand thetherapeutic relevance of glycosides compared to standard vascular and anti-diabetic drugs.Constituent Avocado Seed Glycosides (ASG) were analysed and administered to rats withDiabetes-Induced Vascular Damage (DIVD).Methods: The rats were first administered with streptozotocin and screened after seven days foralterations in blood glucose, insulin, vascular cell adhesion molecule (VCAM-1), Von Willebrandfactor (VWF), Renin-Angiotensin-Aldosterone System (RAS), eNOx, and endothelin-1 (ET-1).Only rats that satisfied these criteria were recruited and treated with either glibenclamide, met.su +losart, or 200 mg/kg body weight ASG for 28 days.Results: There was an abundance of digitoxin (13.41 mg/100g), digoxin (17.98 mg/100g),avicularin (165.85 mg/100g), and hyperoside (282.51 mg/100g). ASG or met.su + losart exhibitedslight modulatory properties on glucose homeostasis. Rats with DIVD showed elevated renin,angiotensin, VCAM-1 and Lp-PLA2 levels but slightly decreased with glibenclamide treatment andnormalized with ASG or met.su + losart administration. All treatments normalized Hcy levels.DIVD caused the overproduction of CnT, LDH, Crt-K, LDL-c, TG, and TC and suppressed HDL-cbut was completely normalized by the ASG. Water intake remained altered in treated rats.Conclusion: The ASG had no relevant effect on glucose homeostasis during DIVD but showedsignificant vasoprotective properties.