Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease

Dreesen Erwin; Berends Sophie; Laharie David; DHaens Geert; Vermeire Severine; Gils Ann; Mathot Ron

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Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease

机译：克罗恩病患者粪便抑制，粪便冲击，粪便冲击素和内镜缓解关系的建模

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Aims Evidence for the benefits of pharmacokinetic (PK) and pharmacodynamic (PD) monitoring of infliximab in patients with Crohn's disease (CD) remains scarce. We aimed to develop a population (pop)PK/PD model to characterise the infliximab dose-exposure-biomarker-response (faecal calprotectin [fCal] and endoscopic remission [ER]) relationship.

机译：目的：关于英夫利昔单抗在克罗恩病（CD）患者中的药代动力学（PK）和药效学（PD）监测益处的证据仍然很少。我们旨在开发一个群体（pop）PK/PD模型，以描述英夫利昔单抗剂量暴露生物标记物反应（粪便钙卫蛋白[fCal]和内镜缓解[ER]）关系。

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来源
《British Journal of Clinical Pharmacology》 |2021年第1期|共13页
作者
Dreesen Erwin; Berends Sophie; Laharie David; DHaens Geert; Vermeire Severine; Gils Ann; Mathot Ron;
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作者单位

Katholieke Univ Leuven Dept Pharmaceut &

Pharmacol Sci O&

N 2 Herestr 49 Bus 820 B-3000 Leuven;

Amsterdam UMC Hosp Pharm Amsterdam Netherlands;

Bordeaux UMC Haut Levegue Hosp Dept Hepatogastroenterol &

Digest Oncol Bordeaux France;

Amsterdam UMC Dept Gastroenterol &

Hepatol Amsterdam Netherlands;

Univ Hosp Leuven Dept Gastroenterol &

Hepatol Leuven Belgium;

Katholieke Univ Leuven Dept Pharmaceut &

Pharmacol Sci O&

N 2 Herestr 49 Bus 820 B-3000 Leuven;

Amsterdam UMC Hosp Pharm Amsterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Crohn's disease; infliximab; pharmacometrics; population pharmacokinetics-pharmacodynamics; therapeutic drug monitoring;

机译：克罗恩病;英夫利昔单抗;药物测量学;人口药代动力学 - 药效学;治疗药物监测;

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1. Cystic fibrosis and Crohn’s disease:Successful treatment and long term remission with infliximab [J] . Francesca, Vincenzi, Barbara, 世界胃肠病学杂志：英文版 . 2010,第015期
2. Letter to Dreesen et al. on their article "Modelling of the Relationship Between Infliximab Exposure, Faecal Calprotectin, and Endoscopic Remission in Patients With Crohn's Disease"-A comprehensive review of infliximab population pharmacokinetic modelling publications [J] . Le Tilly Olivier, Bejan-Angoulvant Theodora, Paintaud Gilles, British Journal of Clinical Pharmacology . 2021,第3期

机译：德莱森等人。关于他们的文章“毛细血管暴露，粪便抗癌素，患者患者内镜缓解患者的关系的建模” - 富胎巴比人群药代动力学造型出版物的全面综述
3. Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease [J] . Francisco Guilherme Cancela e Penna, Rodrigo Macedo Rosa, Pedro Ferrari Sales da Cunha, BMC Gastroenterology . 2020,第1期

机译：粪便钙普罗茨蛋白是最佳区分克罗恩病中不同程度的内窥镜活动的生物标志物
4. De-escalation of Infliximab Maintenance Therapy from 8-to 10-week Dosing Interval Based on Faecal Calprotectin in Patients with Crohn's Disease [J] . Papamichael Konstantinos, Karatzas Pantelis, Mantzaris Gerasimos J. Journal of Crohn’s & colitis . 2016,第3期

机译：基于粪便钙卫蛋白的克罗恩病患者，英夫利昔单抗维持治疗从8到10周给药间隔的降级
5. Understanding Crohn's disease patients reaction to infliximab from facebook: A medical perspective [C] . M. Roccetti, P. Salomoni, C. Prandi, Proceedings of the 2016 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining . 2016

机译：从facebook了解克罗恩病患者对英夫利昔单抗的反应：医学观点
6. A Cost-utility Analysis of Biosimilar Infliximab Compared to Reference Infliximab in Adult Switch Patients with Crohn's Disease: A Canadian Analysis [D] . Hughes, Avery. 2018

机译：生物纤维生素infiximab的成本实用性分析与成人交换患者参考incriximab患者克罗恩病患者：加拿大分析
7. Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease [O] . Francisco Guilherme Cancela e Penna, Rodrigo Macedo Rosa, Pedro Ferrari Sales da Cunha, 2020

机译：粪便钙卫蛋白是克罗恩病中最能区分缓解与内镜活动程度不同的生物标志物
8. Letter to Dreesen et al. on their article “Modelling of the Relationship Between Infliximab Exposure, Faecal Calprotectin, and Endoscopic Remission in Patients With Crohn's Disease”—A comprehensive review of infliximab population pharmacokinetic modelling publications [O] . Olivier Le Tilly, Theodora Bejan‐Angoulvant, Gilles Paintaud, 2020

机译：德莱森等人的信。关于他们的文章“毛细血管曝光，粪便抗突素，患有克罗恩病患者内镜缓解的关系的建模” - 富胎动力学建模出版物的全面综述
9. Relationships Among Non-Invasive Predictors of Sudden Cardiac Death During Mental Stress and Exercise In Coronary Artery Disease Patients With Known Arrhythmic Vulnerability [R] . Ghambaryan, A. 2009

机译：已知心律失常易感性的冠状动脉疾病患者心理应激和运动期间心脏猝死的非侵入性预测因素之间的关系

Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease

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