Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells In Vitro

摘要

Esterification of idebenone with commercially available straight-chain aliphatic acids,branched-chain aliphatic acids,aromatic acids,or nonsteroidal anti-inflammatory drugs afforded their corresponding idebenonyl esters(5a-k)in good yield.The values of cell viability for RC-58T cell at 50 uM were 86.3% for 5a,75.9% for 5b,23.4% for 5d,61.2% for 5f,67.9% for 5h,70.6% for 5i,and 49.0% for 5j.