Diabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosis

摘要

Background Coronary collateral vessel development (CVD), i.e., arteriogenesis, is regarded as one of the most important mechanisms-along with angiogenesis-to result in protection of the myocardium. Coronary CVD is associated with a reduction in infarct size, future cardiovascular events and improved survival in patients with occlusive coronary artery disease by enhancing regional perfusion in the chronically ischemic myocardium. In the present study, we aimed to investigate the relation of cardiovascular risk factors and hematological parameters with collateral development in patients with severely stenotic (>= 95 %) and totally occluded coronary artery disease including at least one major coronary artery.