Comparison of reduced-toxicity conditioning protocols using fludarabine, melphalan combined with thiotepa or carmustine in allogeneic hematopoietic cell transplantation

Duque-Afonso Jesus; Ihorst Gabriele; Waterhouse Miguel; Zeiser Robert; Waesch Ralph; Bertz Hartmut; Yuecel Mehtap; Koehler Thomas; Mueller-Quernheim Joachim; Marks Reinhard; Finke Juergen

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Comparison of reduced-toxicity conditioning protocols using fludarabine, melphalan combined with thiotepa or carmustine in allogeneic hematopoietic cell transplantation

机译：氟甲滨的减少毒性调理方案的比较，Melphalan与Thiotepa或Carmustine联合同种异体造血细胞移植

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Conditioning protocol based on fludarabin, melphalan combined with thiotepa (FTM) showed sufficient anti-neoplastic effect and is suitable for patients with impaired lung function prior allo-HCT.

机译：基于Fludarabin的调理方案，Melphalan与Thiotepa（FTM）相结合，表现出足够的抗肿瘤效果，适用于肺功能受损的患者Allo-Hct。

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《Bone marrow transplantation》 |2021年第1期|共11页
作者
Duque-Afonso Jesus; Ihorst Gabriele; Waterhouse Miguel; Zeiser Robert; Waesch Ralph; Bertz Hartmut; Yuecel Mehtap; Koehler Thomas; Mueller-Quernheim Joachim; Marks Reinhard; Finke Juergen;
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作者单位

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Med Ctr Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Med Ctr Freiburg Germany;

Univ Freiburg Med Ctr Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

Univ Freiburg Dept Hematol Oncol Stem Cell Transplantat Fac Med Freiburg Germany;

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正文语种 eng
中图分类治疗学;
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1. Fludarabine and cytarabine combined chemotherapy followed by transfusion of donor blood stem cells for treating relapse of acute leukaemia after allogeneic haematopoietic stem cell transplantation [J] . YOU Yong, LI Qiu-bai, CHEN Zhi-chao, 中华医学杂志（英文版） . 2008,第018期
2. Reduced-toxicity conditioning for allogeneic hematopoietic cell transplantation in elderly or comorbid patients with AML using fludarabine, BCNU and melphalan: disease stage at transplant determines outcome [J] . Wais V., Kuendgen L., Bohl S. R., Bone marrow transplantation . 2018,第1期

机译：使用Fludarabine，BCNU和Melphalan的老年人或可嗜血症患者的同种异体造血细胞移植的减少毒性调理：移植疾病阶段决定了结果
3. Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies. [J] . Marks R, Potthoff K, Hahn J, Blood: The Journal of the American Society of Hematology . 2008,第2期

机译：在异基因造血细胞移植中用氟达拉滨，BCNU和美法仑降低毒性，这对晚期血液系统恶性肿瘤特别有效。
4. Comparison between two fludarabine-based reduced-intensity conditioning regimens before allogeneic hematopoietic stem-cell transplantation: fludarabine|[sol]|melphalan is associated with higher incidence of acute graft-versus-host disease and non-relapse mortality and lower incidence of relapse than fludarabine|[sol]|busulfan [J] . A Shimoni, I Hardan, N Shem-Tov, Leukemia . 2007,第10期

机译：同种异体造血干细胞移植前两种基于氟达拉滨的低强度调理方案的比较：氟达拉滨| [sol] |美法仑与急性移植物抗宿主病发病率高，非复发死亡率和复发率低相关氟达拉滨| [sol] |白消安
5. Fludarabine Phosphete and Melphalan - An Immunosuppressive Reduced Intensity Conditioning (RIC) Regimen for AUogeneic Stem Cell Transplantation in Patients with a Range of Hematological Malignancies [C] . G. Jackson, C. Richardson, G. Morgan, European Haematology Association . 2002

机译：Fludarabine phospete和Melphalan - 一种免疫抑制性降低的强度调理（RIC）治疗患者血液学恶性肿瘤患者的促孕酮干细胞移植方案
6. Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians. [D] . Tay, Jason. 2009

机译：接受同种异体造血干细胞移植的患者的供体选择：加拿大造血干细胞移植医生的优先事项评估。
7. Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial [O] . Tapani Ruutu, Liisa Volin, Dietrich W. Beelen, 2011

机译：在异基因造血干细胞移植中使用硫丹和氟达拉滨降低毒性条件治疗骨髓增生异常综合症：一项国际前瞻性II期临床试验的最终结果
8. Reduced-toxicity conditioning for allogeneic hematopoietic cell transplantation in elderly or comorbid patients with AML using fludarabine, BCNU and melphalan: disease stage at transplant determines outcome [O] . V Wais, L Kündgen, S R Bohl, 2017

机译：使用Fludarabine，BCNU和Melphalan的老年人或可嗜血症患者的同种异体造血细胞移植的减少毒性调理：移植疾病阶段决定了结果
9. Graft Versus Host Inhibition. IX. The Therapeutic Potential of Combined Fetal Liver and Thymus Cells as a Universal Hematopoietic Stem Cell Source for Transplantation. [R] . Bortin, M. M. 1978

机译：嫁接与宿主抑制。 IX。联合胎肝和胸腺细胞作为通用造血干细胞移植的治疗潜力。

Comparison of reduced-toxicity conditioning protocols using fludarabine, melphalan combined with thiotepa or carmustine in allogeneic hematopoietic cell transplantation

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