Stable bone density in adolescents with severe growth hormone deficiency after six months off rhGH

Schweizer Roland; Donner Julia; von Lukowicz Bettina; Bauer Jana Leonie; Binder Gerhard

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Stable bone density in adolescents with severe growth hormone deficiency after six months off rhGH

机译：在六个月后，青少年骨密度稳定骨密度缺乏速度

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摘要

Objective: Severe growth hormone deficiency causes lean body mass loss in male adolescents and increased fat mass in both sexes. The changes appear after a 6 month GH pause.

机译：目的：严重的生长激素缺乏症导致雄性青少年的瘦体重损失，增加两性脂肪肿块。在6个月GH暂停后，更改出现。

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来源
《Bone》 |2021年第1期|共6页
作者
Schweizer Roland; Donner Julia; von Lukowicz Bettina; Bauer Jana Leonie; Binder Gerhard;
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作者单位

Univ Childrens Hosp Pediat Endocrinol Hoppe Seyler Str 1 D-72076 Tubingen Germany;

Hasbro Childrens Hosp Dept Pediat Providence RI USA;

Univ Childrens Hosp Pediat Endocrinol Hoppe Seyler Str 1 D-72076 Tubingen Germany;

Univ Childrens Hosp Pediat Endocrinol Hoppe Seyler Str 1 D-72076 Tubingen Germany;

Univ Childrens Hosp Pediat Endocrinol Hoppe Seyler Str 1 D-72076 Tubingen Germany;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Growth hormone deficiency; Bone mineral density; Trabecular bone density; Cortical bone density; Strength strain index;

机译：生长激素缺乏;骨密度;小梁骨密度;皮质骨密度;强度应变指数;

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专利

1. Growth Hormone Treatment, Cardiovascular Risk and Autonomic Maturation in Children and Adolescents with Growth Hormone Deficiency or Born Small for Gestational Age [J] . Reiner Buchhorn, Christian Willaschek 儿科学期刊（英文） . 2020,第001期
2. Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency: a Clinical Multidetector Computed Tomography Study [J] . DENG Min, WANG Yi Xiang, James F. GRIFFITH, 生物医学与环境科学（英文版） . 2012,第006期
3. Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center [J] . Gonzalo Allo Miguel, Alicia Serraclara Plá, Myriam Lorena Partida Mu?oz, Therapeutic advances in endocrinology and metabolism. . 2016,第3期

机译：在单个中心接受rhGH替代治疗的生长激素缺乏症成人小梁骨评分，骨矿物质密度，身体成分和生活质量的七年随访
4. Responses of bone turnover markers and bone mineral density to growth hormone therapy in children with isolated growth hormone deficiency and multiple pituitary hormone deficiencies. [J] . Kandemir N, Gonc EN, Yordam N Journal of pediatric endocrinology & metabolism: JPEM . 2002,第6期

机译：骨质周转标志物和骨密度对分离生长激素缺乏的儿童生长激素治疗的反应及多种垂体激素缺陷。
5. Effects of up to 15 years of recombinant human GH (rhGH) replacement on bone metabolism in adults with Growth Hormone Deficiency (GHD): The Leiden Cohort Study [J] . Appelman-DijkstraN.M., ClaessenK.M.J.A., HamdyN.A.T., Clinical Endocrinology . 2014,第5期

机译：长达15年的重组人GH（rhGH）替代对生长激素缺乏症（GHD）成人的骨代谢的影响：莱顿队列研究
6. ORAL DELIVERY OF RECOMBINANT HUMAN GROWTH HORMONE (rhGH) [C] . Puchun Liu, Suraj Kalbag, John Maher, Annual meeting of the Controlled Release Society . 2002

机译：重组人体生长激素（RHGH）的口服递送
7. Exploring the relationship between changes in bone mineral density, lean body mass, and hormones in active, adult males with osteopenia after a 12-month exercise intervention. [D] . Carter, Melissa. 2012

机译：在进行了为期12个月的运动干预后，研究了活跃的成年男性骨质减少的骨矿物质密度，瘦体重和激素变化之间的关系。
8. Seven years of follow up of trabecular bone score bone mineral density body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center [O] . Gonzalo Allo Miguel, Alicia Serraclara Plá, Myriam Lorena Partida Muñoz, 2016

机译：在单个中心接受rhGH替代治疗的生长激素缺乏症成人小梁骨评分骨矿物质密度身体成分和生活质量的七年随访
9. The Impact of Congenital, Severe, Untreated Growth Hormone (GH) Deficiency on Bone Size and Density in Young Adults: Insights from Genetic GH-Releasing Hormone Receptor Deficiency [O] . Hiralal G. Maheshwari, Roger Bouillon, Jos Nijs, 2003

机译：先天性，严重，未经处理的生长激素（GH）缺乏对年轻成年人骨骼大小和密度的影响：遗传治疗释放激素受体缺乏的见解
10. Relationship Between Growth Hormone in vivo Bioactivity, the Insulin- Like Growth Factor-I System and Bone Mineral Density in Young, Physically Fit Men and Women [R] . Nindl, B. C., Pierce, J. R., Durkot, M. J., 2008

机译：生长激素体内生物活性，胰岛素样生长因子-I系统与年轻，身体健康男性和女性骨密度的关系

Stable bone density in adolescents with severe growth hormone deficiency after six months off rhGH

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