Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis

Etani Yuki; Ebina Kosuke; Hirao Makoto; Kitaguchi Kazuma; Kashii Masafumi; Ishimoto Takuya; Nakano Takayoshi; Okamura Gensuke; Miyama Akira; Takami Kenji; Goshima Atsushi; Kanamoto Takashi; Nakata Ken; Yoshikawa Hideki

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Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis

机译：萜壶酰胺和抗rankl单克隆抗体对糖皮质激素诱导的骨质疏松症小鼠骨缺损再生的综合作用

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Objective: The purpose of this study was to examine the effect of single or combination therapy of teriparatide (TPTD) and a monoclonal antibody against the murine receptor activator of nuclear factor.B ligand (antiRANKL Ab) on cancellous and cortical bone regeneration in a mouse model of glucocorticoid-induced osteoporosis (GIOP).

机译：目的：本研究的目的是检测单一或联合治疗萜壶酰胺（TPTD）和单克隆抗体对核因子的核受体激活剂的单克隆抗体对小鼠中的松质和皮质骨再生的影响糖皮质激素诱导的骨质疏松症（GIOP）模型。

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来源
《Bone》 |2020年第1期|共9页
作者
Etani Yuki; Ebina Kosuke; Hirao Makoto; Kitaguchi Kazuma; Kashii Masafumi; Ishimoto Takuya; Nakano Takayoshi; Okamura Gensuke; Miyama Akira; Takami Kenji; Goshima Atsushi; Kanamoto Takashi; Nakata Ken; Yoshikawa Hideki;
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作者单位

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Musculoskeletal Regenerat Med Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871;

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Toyonaka City Hosp Dept Orthopaed Surg 4-14-1 Shibaharacho Toyonaka Osaka 5608565 Japan;

Toyonaka City Hosp Dept Orthopaed Surg 4-14-1 Shibaharacho Toyonaka Osaka 5608565 Japan;

Osaka Univ Div Mat &

Mfg Sci Grad Sch Engn 2-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Div Mat &

Mfg Sci Grad Sch Engn 2-1 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Orthopaed Surg Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Hlth &

Sport Sci Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Osaka Univ Dept Hlth &

Sport Sci Grad Sch Med 2-2 Yamada Oka Suita Osaka 5650871 Japan;

Toyonaka City Hosp Dept Orthopaed Surg 4-14-1 Shibaharacho Toyonaka Osaka 5608565 Japan;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Glucocorticoid-induced osteoporosis; Teriparatide; Anti-RANKL monoclonal antibody; Combination therapy; Bone regeneration;

机译：糖皮质激素诱导的骨质疏松症;Teriparatide;抗Rankl单克隆抗体;联合治疗;骨再生;

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2. New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide [J] . Sakae Tanaka, Taiji Adachi, Tatsuhiko Kuroda, 骨研究（英文版） . 2014,第004期
3. New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide [J] . Sakae Tanaka, Taiji Adachi, Tatsuhiko Kuroda, 骨研究：英文 . 2014,第004期
4. Effects of single or combination therapy of teriparatide and anti-RANKL monoclonal antibody on bone defect regeneration in mice [J] . Kazuma Kitaguchi, Masafumi Kashii, Kosuke Ebina, Bone . 2018,第期

机译：萜或抗rancall单克隆抗体单或组合治疗对小鼠骨缺损再生的影响
5. Effects of single or combination therapy of teriparatide and anti-RANKL monoclonal antibody on bone defect regeneration in mice [J] . Kazuma Kitaguchi, Masafumi Kashii, Kosuke Ebina, Bone . 2018,第期

机译：单萜和抗RANKL单克隆抗体对小鼠骨缺损再生的单一或抗RANKL单克隆抗体的影响
6. Individual and combining effects of anti-RANKL monoclonal antibody and teriparatide in ovariectomized mice [J] . Naoto Tokuyama, Jun Hirose, Yasunori Omata, Bone Reports . 2015,第1期

机译：抗RANKL单克隆抗体和特立帕肽在去卵巢小鼠中的单独作用和联合作用
7. Effects of the orientation of anti-BMP2 monoclonal antibody immobilized on scaffold in antibody mediated osseous regeneration [C] . Sahar Ansari, Marcelo Freire, Moon Gi Choi, Society for Biomaterials annual meeting and exposition . 2015

机译：抗体介导的骨再生中固定在支架上的抗BMP2单克隆抗体定向的影响
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Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis

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