Serum level of Kisspeptin in Pregnant Women with Preeclampsia

摘要

Preeclampsia is major causes of maternal and perinatal mortality and morbidity throughout the world. To diagnose preeclampsia, a large and growing number of biochemical markers have been tested as potential screening tests. Kisspeptin (KP) has recently seems as putative biomarker for preeclampsia. Therefore, the aim of study was to evaluate the sensitivity, specificity and diagnostic accuracy of KP in the second-trimester of pregnancy. This diagnostic study was conducted on 430 women in second-trimester of pregnancy. Serum concentration of KP was measured by standard sandwich enzyme-linked immune-Sorbent assay method. Sensitivity, specificity, accuracy, Likelihood ratio of a Positive and negative Test, positive and negative predictive values of the KP were calculated. Also, receiver operating characteristic (ROC) curves were used.KP mean serum level were 75.56 ± 91.76 (ng/ml) and 34.68 ± 32.86 (ng/ml) in 430 participants, respectively. Serum level of KP for diagnosis of preeclampsia in the second trimester showed that the sensitivity and specificity of the test were 33.33% and 95.36%, respectively. Diagnostic Accuracy of test was 93.27%. Positive Predictive Value and Negative Predictive Value were 20% and 97.62%, respectively. Area in ROC curve shows that possibility of diagnosing preeclampsia with KP serum level is 64.3%. To diagnose the preeclampsia in early pregnancy, KP level is a promising biomarker but regarding to inadequate test sensitivity, it cannot be recommended in screening.