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Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

机译：涉及4-羟基-2-壬比在污染诱导的皮肤损伤中

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Abstract > The effects of environmental insults on human health are a major global concern. Some of the most noxious pollutants that humans are exposed to include ozone (O <sub>3</sub> ), particulate matter (PM), and cigarette smoke (CS). Since the skin is the first line of defense against environmental insults, it is considered one of the main target organs for the harmful insults of air pollution. Thus, there is solid evidence that skin pathologies such as premature aging, atopic dermatitis (AD), and psoriasis are associated with pollutant exposure; all of these skin conditions are also associated with an altered redox status. Therefore, although the mechanisms of action and concentrations of O <sub>3</sub> , PM, and CS that we are exposed to differ, exposure to all of these pollutants is associated with the development of similar skin conditions due to the fact that all of these pollutants alter redox homeostasis, increasing reactive oxygen species production and oxidative stress. A main product of oxidative stress, induced by exposure to the aforementioned pollutants, is 4‐hydroxy‐2‐nonenal (HNE), which derives from the oxidation of ω‐6 polyunsaturated fatty acids. HNE is a highly reactive compound that can form adducts with cellular proteins and even DNA; it is also an efficient cell signaling molecule able to regulate mitogen‐activated protein kinase pathways and the activity of redox‐sensitive transcription factors such as Nrf2, AP1, and NFκB. Therefore, increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >环境侮辱对人类健康的影响是一个主要的全球关注。一些人暴露于臭氧（O <sub> 3 </ sub>），颗粒物（PM）和香烟烟雾（CS）中的一些最有趣的污染物。由于皮肤是对环境侮辱的第一行防御，因此被认为是有害空气污染侮辱的主要目标器官之一。因此，存在稳定的证据，即皮肤病理如过早，特应性皮炎（AD）和牛皮癣与污染物暴露有关;所有这些皮肤状况也与改变的氧化还原状态有关。因此，虽然我们暴露于O <sub> 3 </ sub>，PM和Cs的作用和浓度的机制，但是我们暴露于所有这些污染物的暴露与由于事实为本的皮肤状况的发展有关所有这些污染物都会改变氧化还原稳态，增加反应性氧物种生产和氧化应激。通过暴露于上述污染物引起的氧化应激的主要产物是4-羟基-2-壬酯（HNE），其源于ω-6多不饱和脂肪酸的氧化。 HNE是一种高反应性化合物，可以用细胞蛋白和均匀的DNA形成加合物;它还是一种有效的细胞信号传导分子，能够调节丝裂剂活化的蛋白激酶途径和氧化还原敏感转录因子的活性，例如NRF2，AP1和NFκB。因此，抑制污染物的皮肤中HNE水平增加，可能会加速皮肤衰老并加剧现有的皮肤炎症条件;因此，靶向HNE形成可能是局部应用的创新的化妆方法。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-14799/'>《BioFactors》</a> <b style="margin: 0 2px;">|</b><span>2019年第4期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pecorelli Alessandra&option=202" target="_blank" rel="nofollow">Pecorelli Alessandra;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Woodby Brittany&option=202" target="_blank" rel="nofollow">Woodby Brittany;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prieux Roxane&option=202" target="_blank" rel="nofollow">Prieux Roxane;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Valacchi Giuseppe&option=202" target="_blank" rel="nofollow">Valacchi Giuseppe;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Plants for Human Health Institute Department of Animal SciencesNorth Carolina State UniversityKannapolis North Carolina;</p> <p>Plants for Human Health Institute Department of Animal SciencesNorth Carolina State UniversityKannapolis North Carolina;</p> <p>Department of Life Sciences and BiotechnologyUniversity of FerraraFerrara Italy;</p> <p>Plants for Human Health Institute Department of Animal SciencesNorth Carolina State UniversityKannapolis North Carolina;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ozone&option=203" rel="nofollow">ozone;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=particulate matter&option=203" rel="nofollow">particulate matter;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cigarette smoke&option=203" rel="nofollow">cigarette smoke;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peroxidation&option=203" rel="nofollow">peroxidation;</a> </p> <div class="translation"> 机译：臭氧;颗粒物质;香烟烟雾;过氧化; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-oceanic-limnology-english-edition_thesis/0201252508923.html">Protective Effect of Topically Applied Polypeptide from Chlamys farreri Against Ultraviolet Radiation-Induced Chronic Skin Damage in Guinea Pig</a> <b>[J]</b> . 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L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paromov, V.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Paromov, V.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang, H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang, H. </a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：局部应用脂质体抗氧化剂防止CEEs引起的皮肤损伤;最终的评论。 2005年7月1日至2008年5月30日</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_environmental-science-engineering_thesis/0201273888541.html">Evaluating the Effect of Algal Extracts against Ultraviolet B-Induced Skin Damage in BALB/c Mice</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Abdullah Trad Al-fawwaz&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Abdullah Trad Al-fawwaz</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mariam Abu-AL-Basal&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Mariam Abu-AL-Basal</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hala Ali Tawil&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Hala Ali Tawil</a> <span> <a href="/journal-cn-54856/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 环境科学与工程：B </a> </span> <span> . 2015</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201295610699.html">Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rossella Di Franco&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Rossella Di Franco</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vincenzo Ravo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Vincenzo Ravo</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sara Falivene&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Sara Falivene</a> <span> <a href="/journal-cn-56375/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 化妆品、皮肤病及应用期刊（英文） </a> </span> <span> . 2014</span><span>,第1期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201297057843.html">Diclofenac-Induced Kidney Damage in Wistar Rats: Involvement of Antioxidant Mechanism</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tijani S. Abiola&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Tijani S. Abiola</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oyindamola C. Adebayo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Oyindamola C. Adebayo</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=O. O. Babalola&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,O. O. Babalola</a> <span> <a href="/journal-cn-56593/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物科学与医学（英文） </a> </span> <span> . 2019</span><span>,第12期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201297309259.html">Novel Nitrobenzazolo3,2-aquinolinium Salts Induce Cell Death through a Mechanism Involving DNA Damage, Cell Cycle Changes, and Mitochondrial Permeabilization</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Christian Vélez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Christian Vélez</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Osvaldo Cox&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Osvaldo Cox</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carlos A. Rosado-Berrios&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Carlos A. Rosado-Berrios</a> <span> <a href="/journal-cn-57713/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 细胞凋亡（英文） </a> </span> <span> . 2013</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-39409_thesis/020222420448.html">Air Pollution and Skin Health——From epidemiological and mechanistic studies to clinical implications.</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Liu Wei</a> <span> <a href="/conference-cn-39409/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2016个人护理品技术高峰论坛 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313051119.html">Oxidative stress and cellular damage induced by AFB1 and their amelioration by selenium and beta--carotene</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fahmida Abdul Ghaffar&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Fahmida Abdul Ghaffar</a> <span> . 2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130499752283.html">MEDICATION AND METHOD FOR INHIBITING NONENAL-INDUCED SKIN DAMAGE</a> <b>[P]</b> . <span> 外国专利：  WO2021066109A1 </span> <span> . 2021-04-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：抑制珠骨诱导的皮肤损伤的药物和方法 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130406782796.html">method for producing a stress-induced photosynthetic organism, stress-induced photosynthetic organism, method for isolating an altered bioactive fraction from a stress-induced photosynthetic organism, altered bioactive fraction, bioactive topical formulation suitable for topical application in a mammal, method for inhibiting the inflammatory activity in a mammalian skin tissue, method of protecting a mammalian skin tissue from damage induced by ultraviolet light, method for normalizing skin disorders in a mammalian skin tissue, and system for cultivating induced photosynthetic organisms for stress</a> <b>[P]</b> . <span> 外国专利：  BR112012010978A8 </span> <span> . 2018-06-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：产生胁迫诱导的光合生物的方法，胁迫诱导的光合生物，从胁迫诱导的光合生物中分离改变的生物活性级分的方法，改变的生物活性级分，适合在哺乳动物中局部应用的生物活性局部制剂，哺乳动物皮肤组织中的炎性活性，保护哺乳动物皮肤组织免受紫外线诱导的损害的方法，使哺乳动物皮肤组织中的皮肤疾病正常化的方法以及用于诱导诱导的光合生物的培养系统 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130437808395.html">Marker gene pool, method for assessing the reparative and / or therapeutic protective effects of ultraviolet radiation of a compound or material, compound or material having ultraviolet protective, repairing or therapeutic effects, methods for improving and / or treating, for reversing and / or repair photo-damaged or photo-aged skin, and to assess whether a substance can repair or reverse the effects of photo-damage or photoaging related to UV radiation exposure, substance or material having photo-repairing or reversing effects or photoaging, composition or formulation, photoprotective or photoprotective or anti-photoaging formulation, methods for assessing skin damage or an ultraviolet-induced skin replacement following exposure to uv radiation, to prevent photoaged or photoavariated skin, to identify or select individuals who are susceptible useful or highly sensitive to skin photoaging or photoaging following exposure to UV radiation, and kit for assessing the photoaging or photoag</a> <b>[P]</b> . <span> 外国专利：  BR0209510A </span> <span> . 2006-02-07</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：标记基因库，评估化合物或材料的紫外线的修复和/或治疗保护作用的方法，具有紫外线保护，修复或治疗作用的化合物或材料，改善和/或治疗，逆转和/或修复的方法光损伤或光老化的皮肤，并评估一种物质是否可以修复或逆转与紫外线辐射，光修复或逆转作用或光老化，组成或配方有关的物质或材料的光损伤或光老化的影响，光保护或光保护或抗光老化制剂，评估暴露于uv辐射后皮肤损伤或紫外线引起的皮肤置换，预防光老化或光变皮肤，鉴定或选择对皮肤光老化有用或高度敏感的个体的方法暴露于紫外线辐射后发生光老化，以及用于评估光老化或光敏性的试剂盒 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704028279101','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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