The Nucleic acid Ligand: A New Tool lor Molecular Recognition

摘要

Selective binding through molecu-lar recognition is the basis of many important techniques in chemical analysis and separations, including those that employ enzymes, antibodies, or selective chelators. Reagents such as cyclodextrins that have preferential interaction with one isomer or enantiomer over another, often combined with selectivity based on size or shape, have been used to accomplish chiral or isomeric separations. Affinity-based separations depend on specific molecular recognition betweenimmobilized ligands and their receptors, which are the target analytes. Chemical sensors often use selective binders that are immobilized at the sensor surface to generate an analyte-dependent signal.