The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis

Lunetti Paola; Marsano Rene Massimiliano; Curcio Rosita; Dolce Vincenza; Fiermonte Giuseppe; Cappello Anna Rita; Marra Federica; Moschetti Roberta; Li Yuan; Aiello Donatella; Martinez Araceli del Arco; Lauria Graziantonio; De Leonardis Francesco; Ferramosca Alessandra; Zara Vincenzo; Capobianco Loredana

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The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis

机译：线粒体天冬氨酸/谷氨酸载体（AGC或ARALAR1）在D. melanogaster中的同种型：生物化学表征，基因结构和进化分析

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Background: In man two mitochondrial aspartate/glutamate carrier (AGC) isoforms, known as aralar and citrin, are required to accomplish several metabolic pathways. In order to fill the existing gap of knowledge in Drosophila melanogaster, we have studied aralar1 gene, orthologue of human AGC-encoding genes in this organism.

机译：背景：在MAM中，需要两种线粒体天冬氨酸/谷氨酸载体（AGC）同种型，称为Aralar和Citrin，以实现几种代谢途径。为了填补果蝇的现有知识的差距，我们研究了该生物体中的Aralar1基因，原始人AGC编码基因。

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来源
《Biochimica et Biophysica Acta. General Subjects》 |2021年第5期|共16页
作者
Lunetti Paola; Marsano Rene Massimiliano; Curcio Rosita; Dolce Vincenza; Fiermonte Giuseppe; Cappello Anna Rita; Marra Federica; Moschetti Roberta; Li Yuan; Aiello Donatella; Martinez Araceli del Arco; Lauria Graziantonio; De Leonardis Francesco; Ferramosca Alessandra; Zara Vincenzo; Capobianco Loredana;
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作者单位

Univ Salento Dept Biol &

Environm Sci &

Technol I-73100 Lecce Italy;

Univ Bari Dept Biol I-70125 Bari Italy;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Bari Dept Biosci Biotechnol &

Biopharmaceut I-70125 Bari Italy;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Bari Dept Biol I-70125 Bari Italy;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Calabria Dept Chem I-87036 Cosenza Italy;

Univ Castilla La Mancha Fac Ciencias Medio Ambiente Toledo Spain;

Univ Calabria Dept Pharm Hlth &

Nutr Sci I-87036 Cosenza Italy;

Univ Bari Dept Biosci Biotechnol &

Biopharmaceut I-70125 Bari Italy;

Univ Salento Dept Biol &

Environm Sci &

Technol I-73100 Lecce Italy;

Univ Salento Dept Biol &

Environm Sci &

Technol I-73100 Lecce Italy;

Univ Salento Dept Biol &

Environm Sci &

Technol I-73100 Lecce Italy;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Drosophila melanogaster; CG2139; Aspartate/glutamate carrier (AGC); Aralar; Citrin; Phylogenetic footprint;

机译：果蝇melanogaster;CG2139;天冬氨酸/谷氨酸载体（AGC）;aralar;柠檬蛋白;系统发育足迹;

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2. Genomic Analysis of Mitochondrial Carrier Genes in the Bombyx mori [J] . CAO Jun, SHI Feng 农业科学学报：英文版 . 2012,第010期
3. Genomic structure analysis of SNC6, a progesterone-receptor associated protein gene, and cloning and characterization of its 5＇-flanking region [J] . 曹江, 郑树, 叶景佳, 浙江大学学报：自然科学英文版 . 2002,第001期
4. Genomic structure analysis of SNC6, a progesterone-receptor associated protein gene, and cloning and characterization of its 5'-flanking region . [J] . 浙江大学学报（英文版）（A辑：应用物理和工程） . 2002,第001期
5. Silencing of the mitochondrial NADH shuttle component aspartate–glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets [J] . Blanca Rubi, Francesca Frigerio, Gaelle Chaffard, The biochemical journal . 2009,第3期

机译：INS-1E细胞和大鼠胰岛中线粒体NADH穿梭组分天冬氨酸-谷氨酸载体AGC1 / Aralar1的沉默
6. Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets. [J] . Casimir M, Rubi B, Frigerio F, The Biochemical Journal . 2009,第3期

机译：INS-1E细胞和大鼠胰岛中线粒体NADH穿梭组分天冬氨酸-谷氨酸载体AGC1 / Aralar1的沉默。
7. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate|[sol]|glutamate carrier AGC1 [J] . L Palmieri, V Papaleo, V Porcelli, Molecular Psychiatry . 2010,第1期

机译：自闭症谱系疾病中钙稳态的改变：线粒体天冬氨酸| [sol] |谷氨酸载体AGC1的生化和遗传研究的证据
8. Biochemical and molecular characterization of thyroid tissue by micro-Raman spectroscopy and gene expression analysis [C] . Lazaro P. M. Neto, Airton A. Martin, Claudio A. T. Soto, Photonic therapeutics and diagnostics XII . 2016

机译：甲状腺组织的生化和分子特征的显微拉曼光谱和基因表达分析
9. Cloning and characterization of citrin: The aspartate/glutamate carrier mutated in adult-onset type II citrullinemia. [D] . Sinasac, David Steven. 2003

机译：柠檬酸的克隆和特征：天冬氨酸/谷氨酸携带者在成年发作的II型瓜氨酸血症中突变。
10. De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1 [O] . Beatriz Pardo, Laura Contreras, Jorgina Satrústegui 2013

机译：从头合成年轻小鼠胶质谷氨酸和谷氨酰胺需要神经元线粒体天冬氨酸-谷氨酸载体Aralar / AGC1提供的天冬氨酸。
11. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. [O] . Palmieri, L, Papaleo, V, Porcelli, V, 2010

机译：自闭症谱系疾病中钙稳态的改变：线粒体天冬氨酸/谷氨酸载体AGC1的生化和遗传研究的证据。

The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis

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