Synthesis of a Lipomannan Component of the Cell-Wall Complex of Mycobacterium tuberculosis Is Based on Paulsen's Concept of Donor/Acceptor 'Match'

摘要

The resilience of tuberculosis,evident in the continuing worldwide mortality from this disease,is largely attributable to the dense complex lipoarabinomannan(LAM)capsule that is the major virulence factor of the causative agent Mycobacterium tuberculosis Significant interest stems from recent discoveries showing that LAM exhibits a profound propensity toward immunomodulation,the ability to enhance resistance to various cancers and herpes,and a surprising capacity to potentiate HIV antiretroviral drugs.