Solvent Effect on Crystal Polymorphism:Why Addition of Methanol or Ethanol to Aqueous Solutions Induces the Precipitation of the Least Stable beta Form of Glycine

摘要

Crystal polymorphism,which embodies the ability of molecules to form diverse packing arrangements displaying different physical and chemical characteristics,is of paramount importance in fields such as pharmacology,solid-state chemistry,and material science.However,the conditions to induce the precipitation of various(metastable)poly-morphs is invariably achieved by"mix and try"methods,which are kinetically driven.