Electrochemistry/Mass Spectrometry (EC/MS)-A New Tool To Study Drug Metabolism and Reaction Mechanisms

摘要

The possibility of simulating the oxida-tive metabolism of drugs is only one major reason for the strongly increasing attraction in the on-line coupling between electrochemistry and electro-spray mass spectrometry (EC/MS) for both industry and academia.Although this combination has been known from a few publications for a long time and has been covered by recent reviews,it is now leaving its hibernation phase for good reasons.Some very attractive new applications for EC/MS,partly in combination with liquid chromatography (LC),have recently been published.Herein,the major characteristics of EC/MS are summarized,the most interesting recent applications are discussed,and future perspectives are presented.