An Efficient Synthesis of Diaryl Ketones by Iron-Catalyzed Arylation of Aroyl Cyanides

摘要

The acylation of organometallic intermediates with acid chlorides is an important method for the preparation of polyfunctional ketones.This functionality is present in a great variety of pharmaceutical and material-science target molecules.Many organometallic reagents have been used for performing acylations,and organomanganese reagents have proved to be especially useful.Polyfunctional organozinc compounds have also been used frequently,and smooth acylations can be performed in the presence of stoichiometric amounts of CuCN-2LiCl or in the presence of a palladium catalyst.