Direct, Iridium-Catalyzed Enantioselective and Regioselective Allylic Etherification with Aliphatic Alcohols

摘要

Intermolecular, enantioselective allylic substitution with alcohols remains an undeveloped catalytic process. Few reports have been published that describe the intermolecular allylation of aliphatic alcohols with high yield and enantio-selectivity, and the most selective of these systems has required copper additives. The large number of a chiral ethers and oxygen heterocycles in natural products and pharmaceutical candidates makes enantioselective routes to these materials important.