Widely Applicable Pd-Catalyzed trans-Selective Monoalkylation of Unactivated 1,1-Dichloro-1-alkenes and Pd-Catalyzed Second Substitution for the Selective Synthesis of E or Z Trisubstituted Alkenes

摘要

Since the discovery of the Pd-catalyzed highly trans-selective monosubstitution of 1,1-dihalo-1-alkenes and the subsequent second substitution to produce trisubstituted alkenes [Eq. (1)],[1] its development as a method for not only the selective synthesis of monosubstitution products[2] but also for disubstitution products[1], [2c], [e], [3]-[5] has attracted considerable attention from synthetic chemists.