Monitoring the Progress of Solid-Phase Oligosaccharide Synthesis by High-Resolution Magic Angle Spinning NMR: Observations of Enhanced Selectivity for β-Glycoside Formation from α-1,2-Anhydrosugar Donors in Solid-Phase Couplings

摘要

The vital roles played by oligosaccharides in cell-cell signaling and adhesion have led to greatly increased interest and appreciation of this class of compounds. It is now recognized that these complex biomolecules, in the form of glycoprotein and glycolipid conjugates, carry detailed structural information, which serves to mediate a variety of biological events including inflammation, immunological response, and metastasis. Furthermore, cell-surface carbohydrates act as biological markers for various tumors.