Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles

摘要

Nanoparticles entering the bloodstream may initially bind highly abundant serum/plasma proteins, such as human serum albumin (HSA). We show here that, as a result of its low affinity and fast exchange, HSA is soon replaced by the higher-affinity and slower-exchanging apolipoproteins AI, AII, AIV, and E, and that these proteins remain associated with the particles under the expected conditions of in vivo exposure, thus conferring their biological identity onto the particles.