First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

摘要

The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 integron, itself nested within an similar to 54-kb multidrug resistance region on an epidemic IncA/C-2 plasmid. The emergence of bla(IMP-14) in this context in the ST131 lineage is of potential clinical concern.