Low eosinophil percentages as a new predictive marker for infusion reactions due to trastuzumab

摘要

Background/Aim: Infusion reactions (IRs) often occur with trastuzumab. Although premedication by nonsteroidal anti-inflammatory drugs can be effective to a certain extent, IRs are still common and infrequently severe. Therefore, a predictive marker that can select patients requiring further prophylaxis is useful for appropriate prevention, but remains unclear. Patients and Methods: We conducted a retrospective analysis for 136 consecutive female inpatients aged 18 years and older who received 8 mg/kg of the initial trastuzumab administration for breast cancer with a 25-mg dose of rectal diclofenac before trastuzumab infusion between May 2007 and April 2019, in order to assess IRs. Results: Overall, 57 patients were eligible for inclusion in the study. IRs were observed in 17.5% (10/57) of the patients. Univariate analysis showed that patients with a low eosinophil percentage (d2%) were associated with IRs (p=0.016). Conclusion: A low eosinophil percentage can be a useful new predictive marker for trastuzumab-induced IRs in patients with breast cancer. ?2020 International Institute of Anticancer Research. All rights reserved.