Asymmetric Double Proton Transfer of Excited 1:1 7-Azaindole/Alcohol Complexes with Anomalously Large and Temperature-Independent Kinetic Isotope Effects

摘要

Proton transfer has been attracting considerable attention because it plays a key role in a wide variety of biological and chemical processes.Since the discovery of the double-helix structure of DNA by Watson and Crick in 1953,it has been suggested that the tautomerization of DNA base pairs causes inappropriate pairing of bases to result in point mutations.Photo-induced proton transfers are often considered to be useful for understanding the causes of mutagenesis in DNA replication.