Enantioselective Catalytic Allylation of Carbonyl Groups by Umpolung of -Allyl Palladium Complexes

摘要

The development of catalytic asymmetric C-C bond-forming reactions remains one of the main challenges in organic chemistry. Transformations mediated by transition-metal complexes with properly designed ligands have enabled this challenging synthetic goal to be achieved, often with remarkable results. Among the transition-metal-catalyzed reactions known to form C-C bonds, the palladium-catalyzed allylic substitution developed by Trost and Tsuji stands out as one of the most valuable synthetic tools available.