Highly Active Chiral Ruthenium Catalysts for Asymmetric Cross- and Ring-Opening Cross-Metathesis

摘要

Olefin metathesis has found widespread application in small-molecule synthesis.[1] Its use can be subclassified into three transformations[1a] - ring-opening metathesis, ring-closing metathesis, and cross-metathesis - and one can readily envision an asymmetric variant of each of these reactions (Scheme 1). We report herein the use of highly active chiral ruthenium catalysts for asymmetric ring-opening cross-metathesis (AROCM) and the first example of an asymmetric cross-metathesis (ACM) reaction.