A Simple and Efficient Iron-Catalyzed Intramolecular Hydroamination of Unactivated Olefins

摘要

Nitrogen heterocycles have attracted significant interest among synthetic and medicinal chemists over the years,because they form the core structures and are key synthetic intermediates of natural products.The importance of intramolecular hydroamination in the synthesis of these heterocycles has been widely recognized,and much effort has been made towards exploiting this technique.The most promising hydroaminalion ever reported includes two distinctive metal-catalyzed processes: amine activation and olefin activation.