Organocatalytic Sigmatropic Reactions:Development of a [2,3] Wittig Rearrangement through Secondary Amine Catalysis

摘要

Sigmatropic rearrangements represent a fundamental method for the installation of molecular complexity in organic molecules.Both the [2,3] and [3,3] variations have found widespread use in the chemical synthesis of natural products and medicinal agents.Because of the importance of these reactions,the development of asymmetric methods for sigmatropic rearrangements has attracted significant interest from the synthetic community.