Ortho-TMS Benzaldehyde:An Effective Linchpin for Type II Anion Relay Chemistry(ARC)

摘要

Nature,with beautiful elegance,constructs natural products often in iterative fashion with both superb efficiency and exquisite stereochemical control.For more than 100 years chemists have atempted to mimic the elegance of nature with laboratory syntheses.However,the shortcomings of many synthetic ventures lie in the multistep sequences,often leading to minimum structure augmentation,in conjunction with isolation and purification at each stage,leading to inefficient material advancement.Fortunately,multi-component reactions hold considerable promise of alleviating this inefficiency by orchestrating the conversion of simple starting materials,in a single(one-pot)operation,to advanced intermediates of high structural complexity without the need for multiple isolations and purifications.Towards this end,we recently turned to the development of multicomponent reaction sequences exploiting anion relay chemistry(ARC).