Platinum-Catalyzed Desaturation of Lactams, Ketones, and Lactones

摘要

The development of a general platinum-catalyzed desaturation of N-protected lactams, ketones, and lactones to their conjugated alpha,beta-unsaturated counterparts is reported. The reaction operates under mildly acidic conditions at room temperature or 50 degrees C. It is scalable and tolerates a wide range of functional groups. The complementary reactivity to the palladium-catalyzed desaturation is demonstrated in the efficient conversion of iodide, bromide, and sulfur-containing substrates.