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Water‐Insensitive Synthesis of Poly‐β‐Peptides with Defined Architecture

机译：具有定义架构的多β-肽的水性不敏感合成

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Abstract > Biocompatible and proteolysis‐resistant poly‐β‐peptides have broad applications and are dominantly synthesized via the harsh and water‐sensitive ring‐opening polymerization of β‐lactams in a glovebox or using a Schlenk line, catalyzed by the strong base LiN(SiMe <sub>3</sub> ) <sub>2</sub> . We have developed a controllable and water‐insensitive ring‐opening polymerization of β‐amino acid N‐thiocarboxyanhydrides (β‐NTAs) that can be operated in open vessels to prepare poly‐β‐peptides in high yields, with diverse functional groups, variable chain length, narrow dispersity and defined architecture. These merits imply wide applications of β‐NTA polymerization and resulting poly‐β‐peptides, which is validated by the finding of a HDP‐mimicking poly‐β‐peptide with potent antimicrobial activities. The living β‐NTA polymerization enables the controllable synthesis of random, block copolymers and easy tuning of both terminal groups of polypeptides, which facilitated the unravelling of the antibacterial mechanism using the fluorophore‐labelled poly‐β‐peptide. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 生物相容性和抗蛋白水解的聚β-肽具有广泛的应用，并且通过手套箱中的β-内酰胺的刺激和水敏开环聚合或使用由强基础林催化（Sime <sub> 3 </ sub> 的） <sub> 2 </ sub> 。我们开发了可控和水不敏感的开环聚合的β-氨基酸N-噻吩羧酰酐（β-NTA），其可在开放的容器中操作，以制备高产率的聚β-肽，具有不同的官能团，可变链长，分散性和定义架构。这些优点暗示β-NTA聚合和得到的聚-β-肽的广泛应用，通过发现具有有效的抗微生物活性的HDP模仿聚-β-肽来验证。活性β-NTA聚合使得可控合成随机，嵌段共聚物和易于调整两种多肽的末端组，这促进了使用荧光团标记的聚β-肽的抗菌机理的解开。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第18期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Min&option=202" target="_blank" rel="nofollow">Zhou Min;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiao Ximian&option=202" target="_blank" rel="nofollow">Xiao Ximian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cong Zihao&option=202" target="_blank" rel="nofollow">Cong Zihao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Yueming&option=202" target="_blank" rel="nofollow">Wu Yueming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Wenjing&option=202" target="_blank" rel="nofollow">Zhang Wenjing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ma Pengcheng&option=202" target="_blank" rel="nofollow">Ma Pengcheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Sheng&option=202" target="_blank" rel="nofollow">Chen Sheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Haodong&option=202" target="_blank" rel="nofollow">Zhang Haodong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Danfeng&option=202" target="_blank" rel="nofollow">Zhang Danfeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Donghui&option=202" target="_blank" rel="nofollow">Zhang Donghui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luan Xiangfeng&option=202" target="_blank" rel="nofollow">Luan Xiangfeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mai Yiyong&option=202" target="_blank" rel="nofollow">Mai Yiyong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Runhui&option=202" target="_blank" rel="nofollow">Liu Runhui;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> <p>School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240 China;</p> <p>School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240 China;</p> <p>State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymerization&option=203" rel="nofollow">polymerization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=poly-β-peptides&option=203" rel="nofollow">poly-β-peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=secondary structure&option=203" rel="nofollow">secondary structure;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=water-insensitive polymerization&option=203" rel="nofollow">water-insensitive polymerization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=β-NTA&option=203" rel="nofollow">β-NTA;</a> </p> <div class="translation"> 机译：聚合;聚β-肽;二级结构;水不敏感的聚合;β-NTA; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div 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