A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy

Zhang Qi; Wu Jiaojiao; Wang Jingjing; Wang Xia; Wu Chu; Chen Mengwei; Wu Qing; Lesniak Maciej S.; Mi Yongli; Cheng Yu; Wang Qigang

摘要

Abstract > Neutrophils can responsively release reactive oxygen species (ROS) to actively combat infections by exogenous stimulus and cascade enzyme catalyzed bio‐oxidation. A supramolecular nanogel is now used as an artificial neutrophil by enzymatic interfacial self‐assembly of peptides (Fmoc‐Tyr(H <sub>2</sub> PO <sub>3</sub> )‐OH) with magnetic nanoparticles (MNPs) and electrostatic loading of chloroperoxidase (CPO). The MNPs within the nanogel can elevate H <sub>2</sub> O <sub>2</sub> levels in cancer cells under programmed alternating magnetic field (AMF) similar to the neutrophil activator, and the loaded CPO within protective peptides nanolayer converts the H <sub>2</sub> O <sub>2</sub> into singlet oxygen ( 1 O <sub>2</sub> ) in a sustained manner for neutrophil‐inspired tumor therapy. As a proof of concept study, both the H <sub>2</sub> O <sub>2</sub> and 1 O <sub>2</sub> in cancer cells increase stepwise under a programmed alternating magnetic field. An active enzyme dynamic therapy by magnetically stimulated oxygen stress and sustained enzyme bio‐oxidation is thus shown with studies on both cells and animals. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 中性粒细胞可以反应地释放反应性氧物种（ROS）以通过外源刺激和级联酶催化生物氧化积极地对抗感染。通过肽的酶促界面自组装（FMOC-TYR（H. <sub> 2 </ sub> 宝 <sub> 3 </ sub> 用磁性纳米颗粒（MNP）和氯氧化酶（CPO）的静电负载，哦）。纳米凝电池内的MNP可以升高H. <sub> 2 </ sub> O. <sub> 2 </ sub> 编程的交替磁场（AMF）下的癌细胞水平相对于中性粒细胞活化剂，并且保护肽内的负载CPO导致H <sub> 2 </ sub> O. <sub> 2 </ sub> 进入单线时氧气（ 1 </ sup> O. <sub> 2 </ sub> ）以中性粒细胞灵感的肿瘤治疗的持续态度。作为概念研究证明，都是H <sub> 2 </ sub> O. <sub> 2 </ sub> 和 1 </ sup> O. <sub> 2 </ sub> 在癌细胞下在编程的交流场下逐步增加。因此，通过对细胞和动物的研究显示了通过磁刺激氧胁迫和持续酶生物氧化的活性酶动态治疗。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第9期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Qi&option=202" target="_blank" rel="nofollow">Zhang Qi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Jiaojiao&option=202" target="_blank" rel="nofollow">Wu Jiaojiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jingjing&option=202" target="_blank" rel="nofollow">Wang Jingjing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Xia&option=202" target="_blank" rel="nofollow">Wang Xia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Chu&option=202" target="_blank" rel="nofollow">Wu Chu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Mengwei&option=202" target="_blank" rel="nofollow">Chen Mengwei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Qing&option=202" target="_blank" rel="nofollow">Wu Qing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lesniak Maciej S.&option=202" target="_blank" rel="nofollow">Lesniak Maciej S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mi Yongli&option=202" target="_blank" rel="nofollow">Mi Yongli;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cheng Yu&option=202" target="_blank" rel="nofollow">Cheng Yu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Qigang&option=202" target="_blank" rel="nofollow">Wang Qigang;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> <p>Institute for Regenerative MedicineTongji University School of Medicine1800 Yuntai Road Shanghai China;</p> <p>Institute for Regenerative MedicineTongji University School of Medicine1800 Yuntai Road Shanghai China;</p> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> <p>Institute for Regenerative MedicineTongji University School of Medicine1800 Yuntai Road Shanghai China;</p> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> <p>Feinberg School of MedicineNorthwestern University676 North Saint Clair Street Suite 2210 Chicago USA;</p> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> <p>Institute for Regenerative MedicineTongji University School of Medicine1800 Yuntai Road Shanghai China;</p> <p>School of Chemical Science and EngineeringTongji University1239 Siping Road Shanghai China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bio-oxidation&option=203" rel="nofollow">bio-oxidation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cancer therapy&option=203" rel="nofollow">cancer therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanogels&option=203" rel="nofollow">nanogels;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=reactive oxygen species&option=203" rel="nofollow">reactive oxygen species;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=self-assembly&option=203" rel="nofollow">self-assembly;</a> </p> <div class="translation"> 机译：生物氧化;癌症疗法;纳米凝块;反应性氧物种;自组装; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> 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