Self-Assembled Bidentate Ligands for Ru-Catalyzed anti-Markovnikov Hydration of Terminal Alkynes

摘要

The regioselective functionalization of terminal alkynes is a fundamental process in organic synthesis since it allows the installation of a variety of important functional groups into an existing carbon skeleton.Among these reactions,the addition of water across a triple bond generally follows the Markovnikov rule.On the other hand,an anti-Markovnikov hydration of terminal alkynes could be a convenient way to the preparation of aldehydes,but so far only a few ruthenium complexes have been identified which allowed the catalysis of this unusual hydration mode.