Wnt6: another player in the yin and yang of renal Wnt signaling

摘要

diabetic nephropathy (DN) remains the single most common cause of end-stage kidney disease, necessitating dialysis or transplantation, in the Western world. Hence, novel therapies beyond tight blood pressure and glycemic control are required to slow or reverse progression of nephropathy in patients with diabetes. While significant efforts have been made to understand the molecular basis of DN, further delineation of the final common pathway of renal fibrosis, where the functioning nephrons are replaced by scar tissue, may identify novel therapeutic targets.