Mechanistic Insight into the Diastereoselective Rhodium-Catalyzed Pauson-Khand Reaction:Role of Coordination Number in Stereocontrol

摘要

Transition-metal-catalyzed higher-order [m + n + o] carbo-cyclization reactions represent powerful methods for the construction of complex polycyclic systems.A key feature in these transformations is the dichotomy in reactivity that a substrate will display with different transition-metal complexes,reminiscent of enzyme-directed terpene biosynthesis.