Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction

摘要

The available data on the effect of antioxidant therapy on progression of renal disease are limited. Administration of the superoxide dismutase mimetic drug tempol for 2 wk has been shown to ameliorate hypertension without altering renal function in 5/6 nephrectomized rats (48). In a recent study, Tain et al. (40) found significant reduction of glomerulosclerosis but no change in creatinine clearance or proteinuria with vitamin E supplementation for 15 wk in 5/6 nephrectomized rats. Similar findings were reported by Van den Branden et al. (43) and Hahn et al. (7), It should be noted that the use of high doses of antioxidant vitamins in humans has been hampered by the general lack of significant demonstrable benefit and the emerging evidence of adverse outcome found in clinical trials (18). This is not entirely surprising since oxidative stress and the accompanying inflammation in renal disease, cardiovascular disorders, and cancer are not usually caused by deficiencies of the given vitamins.